NEW METHOD OF MEASURING UROFLOW IN THE RAT BLADDER

被引：2

作者：

CHANCELLOR, MB

BLAIVAS, JG

LEVIN, RM

KAPLAN, SA

OTTER, MW

SCHUSSLER, G

机构：

[1] Department of Urology, Jefferson Medical College, Thomas Jefferson University, Philadelphia, Pennsylvania

[2] Department of Urology, University of Pennsylvania, Philadelphia

[3] Orthopaedic Engineering and Research Center, Helen Hayes Hospital, West Haverstraw, New York

[4] Department of Urology, College of Physicians and Surgeons, Columbia University, New York, New York

来源：

NEUROUROLOGY AND URODYNAMICS | 1992年 / 11卷 / 02期

关键词：

UROFLOW; CONDUCTANCE; FLOW RATE;

D O I：

10.1002/nau.1930110207

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

Urodynamic evaluation of bladder function requires the simultaneous measurement of detrusor pressure and uroflow. Although the rat is a common animal model to study several bladder dysfunctions, including partial outlet obstruction, one of the major problems is that the bladder capacity has been too small for the measurement of uroflow. We have developed a new method of measuring uroflow in the rat that is sensitive at low bladder volumes. The method is based on the change in conductance of the gap between two silver electrodes in a measuring chamber as the chamber fills with saline during voiding. An AC voltage supply drives a current through the saline. As the saline level rises in the chamber the conductance increases, with a corresponding increase in current flow. A linear correlation between time rate of change of electrical current and fluid flow rate exists over a wide range of values and suggests that this new rat flowmeter is both accurate and reproducible.

引用

页码：123 / 129

页数：7

共 12 条

[1] Chapman BLW, Charlesworth D, An analysis of ultrasound velocity waveforms in the wake of a stenosis, Vase Diagn Ther, 14, (1983)
[2] Chun AL, Wallace LJ, Gerald MC, Wein AJ, Levin RM, Functional whole rat bladder model, Neurourol Urodyn, 8, (1989)
[3] Chun AL, Wallace LJ, Gerald MC, Wein AJ, Levin RM, Effects of age on urinary bladder function in the male rat, J Urol, 141, (1989)
[4] Dail WG, Evan AP, Eason HR, The major ganglion in the pelvic plexus of the male rat, Cell Tissue Res, 159, (1975)
[5] Gabella G, Autonomic Nervous System, The Rat Nervous System, 2, pp. 325-353, (1985)
[6] Griffiths DJ, van Mastrigt R, The routine assessment of detrusor contraction strength, Neurourol Urodyn, 4, (1985)
[7] Griffiths DJ, Constantinou CE, van Mastrigt R, Urinary bladder function and its control in healthy females, Am J Physiol, 2, (1986)
[8] Kaplan SA, Blaivas JG, Brown WC, Levin RM, Parameters of detrusor contractility: I: The effects of electrical stimulation, hysteresis, and bladder volume in an in‐vitro whole rabbit bladder model, Neurourol Urodyn, 10, (1991)
[9] Langworth OR, Innervation of the pelvic organs of the rat, Invest Urol, 2, (1965)
[10] Quinlan DM, Nelson RJ, Partin AW, Mostwin JL, Walsh PC, The rat as a model for the study of penile erection, J Urol, 141, (1989)

← 1 2 →