THE 5-HT1D RECEPTOR ANTAGONIST GR-127,935 IS AN AGONIST AT CLONED HUMAN 5-HT1D-ALPHA RECEPTOR-SITES

被引：55

作者：

PAUWELS, PJ

COLPAERT, FC

机构：

[1] Centre de Recherche Pierre Fabre, Laboratory of Cellular and Molecular Neurobiology, 81106 Castres CEDEX

来源：

NEUROPHARMACOLOGY | 1995年 / 34卷 / 02期

关键词：

CLONED HUMAN 5-HTID-ALPHA RECEPTOR; CAMP; GR 127,935; KETANSERIN; TRANSFECTED RAT C6-GLIAL CELLS;

D O I：

10.1016/0028-3908(95)00007-S

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The cAMP response of the 5-HT1D receptor antagonist GR 127,935 was compared with 5-CT and ketanserin at cloned human 5-HT1D alpha receptor sites in transfected C6-glial cells. GR 127,935 showed marked agonist activity (EC(50)-value: 141 nM), its maximal effect being comparable to that of the agonist 5-CT (EC(50)-value: 0.91 nM), unlike the apparently silent antagonist ketanserin (K-B-value: 34 nM).

引用

页码：235 / 237

页数：3

共 10 条

[1]

HAMBLIN MW, 1991, MOL PHARMACOL, V40, P143

[2]

HAMEL E, 1993, MOL PHARMACOL, V44, P242

[3] HUMAN ARTERIAL CONSTRICTOR SEROTONIN RECEPTORS [J].