Human lysosomal alpha-mannosidase has been purified by a simple and rapid method in sufficient quantities for the analysis of its subunit composition and partial protein sequencing. Analysis of the N-terminal residues of the 30 kDa polypeptide has enabled a for us to confirm the identity of the recently cloned cDNA that was tentatively identified as that of lysosomal alpha-mannosidase [Nebes and Schmidt (1994) Biochem. Biophys. Res. Commun. 200, 239-245] and to locate the position of this polypeptide within the total deduced amino acid sequence. This finding will therefore provide a firm foundation for the characterization of alpha-mannosidosis mutations.
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UNIV LONDON QUEEN ELIZABETH COLL, DEPT BIOCHEM,MRC,HUMAN GENET DIS RES GRP, CAMPDEN HILL RD, LONDON W8 7AH, ENGLANDUNIV LONDON QUEEN ELIZABETH COLL, DEPT BIOCHEM,MRC,HUMAN GENET DIS RES GRP, CAMPDEN HILL RD, LONDON W8 7AH, ENGLAND
CHENG, SH
MALCOLM, S
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UNIV LONDON QUEEN ELIZABETH COLL, DEPT BIOCHEM,MRC,HUMAN GENET DIS RES GRP, CAMPDEN HILL RD, LONDON W8 7AH, ENGLANDUNIV LONDON QUEEN ELIZABETH COLL, DEPT BIOCHEM,MRC,HUMAN GENET DIS RES GRP, CAMPDEN HILL RD, LONDON W8 7AH, ENGLAND
MALCOLM, S
PEMBLE, S
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UNIV LONDON QUEEN ELIZABETH COLL, DEPT BIOCHEM,MRC,HUMAN GENET DIS RES GRP, CAMPDEN HILL RD, LONDON W8 7AH, ENGLANDUNIV LONDON QUEEN ELIZABETH COLL, DEPT BIOCHEM,MRC,HUMAN GENET DIS RES GRP, CAMPDEN HILL RD, LONDON W8 7AH, ENGLAND
PEMBLE, S
WINCHESTER, B
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UNIV LONDON QUEEN ELIZABETH COLL, DEPT BIOCHEM,MRC,HUMAN GENET DIS RES GRP, CAMPDEN HILL RD, LONDON W8 7AH, ENGLANDUNIV LONDON QUEEN ELIZABETH COLL, DEPT BIOCHEM,MRC,HUMAN GENET DIS RES GRP, CAMPDEN HILL RD, LONDON W8 7AH, ENGLAND
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UNIV LONDON QUEEN ELIZABETH COLL, DEPT BIOCHEM,MRC,HUMAN GENET DIS RES GRP, CAMPDEN HILL RD, LONDON W8 7AH, ENGLANDUNIV LONDON QUEEN ELIZABETH COLL, DEPT BIOCHEM,MRC,HUMAN GENET DIS RES GRP, CAMPDEN HILL RD, LONDON W8 7AH, ENGLAND
CHENG, SH
MALCOLM, S
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UNIV LONDON QUEEN ELIZABETH COLL, DEPT BIOCHEM,MRC,HUMAN GENET DIS RES GRP, CAMPDEN HILL RD, LONDON W8 7AH, ENGLANDUNIV LONDON QUEEN ELIZABETH COLL, DEPT BIOCHEM,MRC,HUMAN GENET DIS RES GRP, CAMPDEN HILL RD, LONDON W8 7AH, ENGLAND
MALCOLM, S
PEMBLE, S
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UNIV LONDON QUEEN ELIZABETH COLL, DEPT BIOCHEM,MRC,HUMAN GENET DIS RES GRP, CAMPDEN HILL RD, LONDON W8 7AH, ENGLANDUNIV LONDON QUEEN ELIZABETH COLL, DEPT BIOCHEM,MRC,HUMAN GENET DIS RES GRP, CAMPDEN HILL RD, LONDON W8 7AH, ENGLAND
PEMBLE, S
WINCHESTER, B
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UNIV LONDON QUEEN ELIZABETH COLL, DEPT BIOCHEM,MRC,HUMAN GENET DIS RES GRP, CAMPDEN HILL RD, LONDON W8 7AH, ENGLANDUNIV LONDON QUEEN ELIZABETH COLL, DEPT BIOCHEM,MRC,HUMAN GENET DIS RES GRP, CAMPDEN HILL RD, LONDON W8 7AH, ENGLAND