OVEREXPRESSING CU/ZN SUPEROXIDE-DISMUTASE ENHANCES SURVIVAL OF TRANSPLANTED NEURONS IN A RAT MODEL OF PARKINSONS-DISEASE

被引：123

作者：

NAKAO, N

FRODL, EM

WIDNER, H

CARLSON, E

EGGERDING, FA

EPSTEIN, CJ

BRUNDIN, P

机构：

[1] WAKAYAMA MED COLL,DEPT NEUROL SURG,WAKAYAMA,JAPAN

[2] UNIV CALIF SAN FRANCISCO,DEPT PEDIAT,SAN FRANCISCO,CA 94143

来源：

NATURE MEDICINE | 1995年 / 1卷 / 03期

关键词：

D O I：

10.1038/nm0395-226

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A high survival rate of grafted dopamine neurons is crucial for reversing neurological deficits following brain tissue transplantation in Parkinson's disease. For unknown rea-sons the survival rate of transplanted dopamine neurons is only around 10% in experimental animals. The hypothesis that oxidative stress causes the loss of transplanted neurons was tested by grafting neurons from transgenic mice that overexpress Cu/Zn superoxide dismutase. Compared with the survival of those taken from non-transgenic littermates, the survival was 4 times higher for the transgenic dopamine neurons with a concomitant more extensive functional recovery. The results provide direct support for the free radical hypothesis of dopaminergic neuron death in brain tissue grafting.

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页码：226 / 231

页数：6

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