A computational method to determine cross-section requirements quantitatively is described and applied to the Tokamak Fusion Test Reactor (TFTR). Perturbation theory is used to combine estimated cross-section uncertainties with calculated sensitivities to determine the variance of any nuclear design parameter of interest. The theory for cross-section sensitivity and uncertainty analysis is extended, and formulas are given for convenient upper-limit estimates for the variance of integral design parameters due to estimated cross-section uncertainties.