COMPARISON OF CLASTOGENICITY OF INORGANIC MN ADMINISTERED IN CATIONIC AND ANIONIC FORMS INVIVO

被引：25

作者：

JOARDAR, M ^{[1
]}

SHARMA, A ^{[1
]}

机构：

[1] UNIV CALCUTTA, DEPT BOT, CTR ADV STUDY CELL & CHROMOSOME RES, GENET TOXICOL UNIT, Kolkata 700019, W BENGAL, INDIA

来源：

MUTATION RESEARCH | 1990年 / 240卷 / 03期

关键词：

Cytotoxicity; Manganese; cationic or anionic;

D O I：

10.1016/0165-1218(90)90055-7

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

A comparison of the cytotoxic activity of cationic (MnSO4) and anionic (KMnO4) salts of inorganic manganese in the mouse in vivo indicated that the former was more strongly clastogenic than the latter. Mice were administered different doses of the salt orally over a period of 3 weeks. In general, both the frequencies of chromosomal aberrations in bone marrow cells and micronuclei were increased significantly by both salts. Sperm-head abnormalities showed a significant enhancement as well. The clastogenic effects were directly related to the concentrations used and were not markedly influenced by the duration of treatment. In view of the known affinity of Mn2+ for chromosomal components, it has been suggested that the effects were medicated by these ions produced directly from MnSO4 and indirectly from KMnO4 following conversion under acidic pH of the gastric juices. © 1990.

引用

页码：159 / 163

页数：5

共 30 条

[1] INCREASED GABA CONTENT IN CAUDATE-NUCLEUS OF RATS AFTER CHRONIC MANGANESE CHLORIDE ADMINISTRATION [J].