METABOLIC-ACTIVATION OF QUERCETIN MUTAGENICITY

被引：22

作者：

VRIJSEN, R ^{[1
]}

MICHOTTE, Y ^{[1
]}

BOEYE, A ^{[1
]}

机构：

[1] VRIJE UNIV BRUSSELS,DEPT PHARMACEUT CHEM,B-1090 BRUSSELS,BELGIUM

来源：

MUTATION RESEARCH | 1990年 / 232卷 / 02期

关键词：

Metabolic activation; Quercetin; Salmonella/microsome test;

D O I：

10.1016/0027-5107(90)90130-V

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

The mutagenicity of quercetin was reinvestigated using the Salmonella/microsome test. The mutagenicity of quercetin was enhanced by the cytosolic fraction of liver extract (S100) or by ascorbate, and even more by the complete liver supernatant (S9) in the presence of cofactors (NADP and glucose-6-phosphate). The formation of metabolites by the S9 enzymes was demonstrated by reverse-phase HPLC. © 1990.

引用

页码：243 / 248

页数：6

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