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RAPID FIBROBLAST GROWTH FACTOR-INDUCED INCREASES IN PROTEIN-PHOSPHORYLATION AND ORNITHINE DECARBOXYLASE ACTIVITY - REGULATION BY HEPARIN AND COMPARISON TO NERVE GROWTH FACTOR-INDUCED INCREASES
被引:10
作者
:
DAMON, DH
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV TEXAS,HLTH SCI CTR,DEPT PHARMACOL,SAN ANTONIO,TX 78284
DAMON, DH
HALEGOUA, S
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV TEXAS,HLTH SCI CTR,DEPT PHARMACOL,SAN ANTONIO,TX 78284
HALEGOUA, S
DAMORE, P
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV TEXAS,HLTH SCI CTR,DEPT PHARMACOL,SAN ANTONIO,TX 78284
DAMORE, P
WAGNER, JA
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV TEXAS,HLTH SCI CTR,DEPT PHARMACOL,SAN ANTONIO,TX 78284
WAGNER, JA
机构
:
[1]
UNIV TEXAS,HLTH SCI CTR,DEPT PHARMACOL,SAN ANTONIO,TX 78284
[2]
SUNY STONY BROOK,DEPT NEUROBIOL & BEHAV,STONY BROOK,NY 11794
[3]
CHILDRENS HOSP MED CTR,BOSTON,MA 02115
[4]
CORNELL UNIV,SCH MED,DEPT NEUROL & NEUROSURG,ITHACA,NY 14853
[5]
HARVARD UNIV,SCH MED,DEPT PATHOL,BOSTON,MA 02115
来源
:
EXPERIMENTAL CELL RESEARCH
|
1992年
/ 201卷
/ 01期
关键词
:
D O I
:
10.1016/0014-4827(92)90359-G
中图分类号
:
R73 [肿瘤学];
学科分类号
:
100214 ;
摘要
:
Fibroblast growth factors (FGFs), like nerve growth factor (NGF), induce morphological differentiation of PC12 cells. This activity of FGF is regulated by glycosaminoglycans. To further understand the mechanisms of FGF and glycosaminoglycan actions in PC12 cells, we studied the regulation of protein phosphorylation and ornithine decarboxylase (ODC) activity by FGF in the presence and absence of heparin. As with NGF, aFGF and bFGF increased the incorporation of radioactive phosphate into the protein tyrosine hydroxylase (TH). The increase in TH phosphorylation was localized to the tryptic peptide, T3. Both T3 and T1 phosphorylations occur in response to NGF, but there was no evidence that aFGF or bFGF stimulated the phosphorylation of the T1 peptide. This result suggests differential regulation of second messenger systems by NGF and FGF in PC12 cells. Heparin, at a concentration that potentiated aFGF-induced neurite outgrowth 100-fold (100 μg/ml), did not alter the ability of aFGF to increase S6 phosphorylation or ODC activity. One milligram per milliliter of heparin, a concentration that inhibited bFGF-induced neurite outgrowth, also inhibited bFGF-induced increases in S6 phosphorylation and ODC activity. These observations suggest (i) that acidic and basic FGF activate a protein kinase, possibly protein kinase C, resulting in the phosphorylation of peptide T3 of TH; (ii) that the FGFs and NGF share some but not all second messenger systems; (iii) that heparin potentiates aFGF actions and inhibits bFGF actions in PC12 cells via distinct mechanisms; (iv) that heparin does not potentiate the neurite outgrowth promoting activity of aFGF by enhancing binding to its PC12 cell surface receptor; and (v) that heparin may coordinately regulate several activities of bFGF (induction of protein phosphorylation, ODC and neurite outgrowth) via a common mechanism, most likely by inhibiting the productive binding of bFGF to its PC12 cell surface receptor. © 1992.
引用
收藏
页码:154 / 159
页数:6
相关论文
共 28 条
[1]
FIBROBLAST GROWTH-FACTORS ARE PRESENT IN THE EXTRACELLULAR-MATRIX PRODUCED BY ENDOTHELIAL-CELLS INVITRO - IMPLICATIONS FOR A ROLE OF HEPARINASE-LIKE ENZYMES IN THE NEOVASCULAR RESPONSE
BAIRD, A
论文数:
0
引用数:
0
h-index:
0
BAIRD, A
LING, N
论文数:
0
引用数:
0
h-index:
0
LING, N
[J].
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,
1987,
142
(02)
: 428
-
435
[2]
NERVE GROWTH-FACTOR REGULATES GENE-EXPRESSION BY SEVERAL DISTINCT MECHANISMS
CHO, KO
论文数:
0
引用数:
0
h-index:
0
机构:
HARVARD UNIV,SCH MED,DEPT BIOL CHEM & MOLEC PHARMACOL,BOSTON,MA 02115
CHO, KO
SKARNES, WC
论文数:
0
引用数:
0
h-index:
0
机构:
HARVARD UNIV,SCH MED,DEPT BIOL CHEM & MOLEC PHARMACOL,BOSTON,MA 02115
SKARNES, WC
MINSK, B
论文数:
0
引用数:
0
h-index:
0
机构:
HARVARD UNIV,SCH MED,DEPT BIOL CHEM & MOLEC PHARMACOL,BOSTON,MA 02115
MINSK, B
PALMIERI, S
论文数:
0
引用数:
0
h-index:
0
机构:
HARVARD UNIV,SCH MED,DEPT BIOL CHEM & MOLEC PHARMACOL,BOSTON,MA 02115
PALMIERI, S
JACKSONGRUSBY, L
论文数:
0
引用数:
0
h-index:
0
机构:
HARVARD UNIV,SCH MED,DEPT BIOL CHEM & MOLEC PHARMACOL,BOSTON,MA 02115
JACKSONGRUSBY, L
WAGNER, JA
论文数:
0
引用数:
0
h-index:
0
机构:
HARVARD UNIV,SCH MED,DEPT BIOL CHEM & MOLEC PHARMACOL,BOSTON,MA 02115
WAGNER, JA
[J].
MOLECULAR AND CELLULAR BIOLOGY,
1989,
9
(01)
: 135
-
143
[3]
ACIDIC FIBROBLAST GROWTH-FACTOR STIMULATES ADRENAL CHROMAFFIN CELLS TO PROLIFERATE AND TO EXTEND NEURITES, BUT IS NOT A LONG-TERM SURVIVAL FACTOR
CLAUDE, P
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV WISCONSIN, WISCONSIN REG PRIMATE RES CTR, MADISON, WI 53715 USA
CLAUDE, P
PARADA, IM
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV WISCONSIN, WISCONSIN REG PRIMATE RES CTR, MADISON, WI 53715 USA
PARADA, IM
GORDON, KA
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV WISCONSIN, WISCONSIN REG PRIMATE RES CTR, MADISON, WI 53715 USA
GORDON, KA
DAMORE, PA
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV WISCONSIN, WISCONSIN REG PRIMATE RES CTR, MADISON, WI 53715 USA
DAMORE, PA
WAGNER, JA
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV WISCONSIN, WISCONSIN REG PRIMATE RES CTR, MADISON, WI 53715 USA
WAGNER, JA
[J].
NEURON,
1988,
1
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: 783
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790
[4]
NERVE GROWTH-FACTOR ACTION IS MEDIATED BY CYCLIC AMP- AND CA-+2 PHOSPHOLIPID-DEPENDENT PROTEIN-KINASES
CREMINS, J
论文数:
0
引用数:
0
h-index:
0
机构:
HARVARD UNIV,SCH MED,DEPT BIOL CHEM,BOSTON,MA 02115
CREMINS, J
WAGNER, JA
论文数:
0
引用数:
0
h-index:
0
机构:
HARVARD UNIV,SCH MED,DEPT BIOL CHEM,BOSTON,MA 02115
WAGNER, JA
HALEGOUA, S
论文数:
0
引用数:
0
h-index:
0
机构:
HARVARD UNIV,SCH MED,DEPT BIOL CHEM,BOSTON,MA 02115
HALEGOUA, S
[J].
JOURNAL OF CELL BIOLOGY,
1986,
103
(03)
: 887
-
893
[5]
SULFATED GLYCOSAMINOGLYCANS MODIFY GROWTH FACTOR-INDUCED NEURITE OUTGROWTH IN PC12 CELLS
DAMON, DH
论文数:
0
引用数:
0
h-index:
0
机构:
HARVARD UNIV, SCH MED, DANA FARBER CANC INST, DEPT BIOL CHEM & MOLEC PHARMACOL, BOSTON, MA 02115 USA
DAMON, DH
DAMORE, PA
论文数:
0
引用数:
0
h-index:
0
机构:
HARVARD UNIV, SCH MED, DANA FARBER CANC INST, DEPT BIOL CHEM & MOLEC PHARMACOL, BOSTON, MA 02115 USA
DAMORE, PA
WAGNER, JA
论文数:
0
引用数:
0
h-index:
0
机构:
HARVARD UNIV, SCH MED, DANA FARBER CANC INST, DEPT BIOL CHEM & MOLEC PHARMACOL, BOSTON, MA 02115 USA
WAGNER, JA
[J].
JOURNAL OF CELLULAR PHYSIOLOGY,
1988,
135
(02)
: 293
-
300
[6]
HEPARIN POTENTIATES THE ACTION OF ACIDIC FIBROBLAST GROWTH-FACTOR BY PROLONGING ITS BIOLOGICAL HALF-LIFE
DAMON, DH
论文数:
0
引用数:
0
h-index:
0
机构:
HARVARD UNIV,SCH MED,DANA FARBER CANC INST,DIV PEDIAT ONCOL,D910,44 BINNEY ST,BOSTON,MA 02115
DAMON, DH
LOBB, RR
论文数:
0
引用数:
0
h-index:
0
机构:
HARVARD UNIV,SCH MED,DANA FARBER CANC INST,DIV PEDIAT ONCOL,D910,44 BINNEY ST,BOSTON,MA 02115
LOBB, RR
DAMORE, PA
论文数:
0
引用数:
0
h-index:
0
机构:
HARVARD UNIV,SCH MED,DANA FARBER CANC INST,DIV PEDIAT ONCOL,D910,44 BINNEY ST,BOSTON,MA 02115
DAMORE, PA
WAGNER, JA
论文数:
0
引用数:
0
h-index:
0
机构:
HARVARD UNIV,SCH MED,DANA FARBER CANC INST,DIV PEDIAT ONCOL,D910,44 BINNEY ST,BOSTON,MA 02115
WAGNER, JA
[J].
JOURNAL OF CELLULAR PHYSIOLOGY,
1989,
138
(02)
: 221
-
226
[7]
ORNITHINE DECARBOXYLASE (EC4.1.1.17) ASSAY BASED UPON THE RETENTION OF PUTRESCINE BY A STRONG CATION-EXCHANGE PAPER
DJURHUUS, R
论文数:
0
引用数:
0
h-index:
0
DJURHUUS, R
[J].
ANALYTICAL BIOCHEMISTRY,
1981,
113
(02)
: 352
-
355
[8]
FOLKMAN J, 1988, AM J PATHOL, V130, P393
[9]
FIBROBLAST GROWTH-FACTOR
GOSPODAROWICZ, D
论文数:
0
引用数:
0
h-index:
0
GOSPODAROWICZ, D
NEUFELD, G
论文数:
0
引用数:
0
h-index:
0
NEUFELD, G
SCHWEIGERER, L
论文数:
0
引用数:
0
h-index:
0
SCHWEIGERER, L
[J].
MOLECULAR AND CELLULAR ENDOCRINOLOGY,
1986,
46
(03)
: 187
-
204
[10]
NERVE GROWTH-FACTOR MEDIATES PHOSPHORYLATION OF SPECIFIC PROTEINS
HALEGOUA, S
论文数:
0
引用数:
0
h-index:
0
HALEGOUA, S
PATRICK, J
论文数:
0
引用数:
0
h-index:
0
PATRICK, J
[J].
CELL,
1980,
22
(02)
: 571
-
581
←
1
2
3
→
共 28 条
[1]
FIBROBLAST GROWTH-FACTORS ARE PRESENT IN THE EXTRACELLULAR-MATRIX PRODUCED BY ENDOTHELIAL-CELLS INVITRO - IMPLICATIONS FOR A ROLE OF HEPARINASE-LIKE ENZYMES IN THE NEOVASCULAR RESPONSE
BAIRD, A
论文数:
0
引用数:
0
h-index:
0
BAIRD, A
LING, N
论文数:
0
引用数:
0
h-index:
0
LING, N
[J].
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,
1987,
142
(02)
: 428
-
435
[2]
NERVE GROWTH-FACTOR REGULATES GENE-EXPRESSION BY SEVERAL DISTINCT MECHANISMS
CHO, KO
论文数:
0
引用数:
0
h-index:
0
机构:
HARVARD UNIV,SCH MED,DEPT BIOL CHEM & MOLEC PHARMACOL,BOSTON,MA 02115
CHO, KO
SKARNES, WC
论文数:
0
引用数:
0
h-index:
0
机构:
HARVARD UNIV,SCH MED,DEPT BIOL CHEM & MOLEC PHARMACOL,BOSTON,MA 02115
SKARNES, WC
MINSK, B
论文数:
0
引用数:
0
h-index:
0
机构:
HARVARD UNIV,SCH MED,DEPT BIOL CHEM & MOLEC PHARMACOL,BOSTON,MA 02115
MINSK, B
PALMIERI, S
论文数:
0
引用数:
0
h-index:
0
机构:
HARVARD UNIV,SCH MED,DEPT BIOL CHEM & MOLEC PHARMACOL,BOSTON,MA 02115
PALMIERI, S
JACKSONGRUSBY, L
论文数:
0
引用数:
0
h-index:
0
机构:
HARVARD UNIV,SCH MED,DEPT BIOL CHEM & MOLEC PHARMACOL,BOSTON,MA 02115
JACKSONGRUSBY, L
WAGNER, JA
论文数:
0
引用数:
0
h-index:
0
机构:
HARVARD UNIV,SCH MED,DEPT BIOL CHEM & MOLEC PHARMACOL,BOSTON,MA 02115
WAGNER, JA
[J].
MOLECULAR AND CELLULAR BIOLOGY,
1989,
9
(01)
: 135
-
143
[3]
ACIDIC FIBROBLAST GROWTH-FACTOR STIMULATES ADRENAL CHROMAFFIN CELLS TO PROLIFERATE AND TO EXTEND NEURITES, BUT IS NOT A LONG-TERM SURVIVAL FACTOR
CLAUDE, P
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV WISCONSIN, WISCONSIN REG PRIMATE RES CTR, MADISON, WI 53715 USA
CLAUDE, P
PARADA, IM
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV WISCONSIN, WISCONSIN REG PRIMATE RES CTR, MADISON, WI 53715 USA
PARADA, IM
GORDON, KA
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV WISCONSIN, WISCONSIN REG PRIMATE RES CTR, MADISON, WI 53715 USA
GORDON, KA
DAMORE, PA
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV WISCONSIN, WISCONSIN REG PRIMATE RES CTR, MADISON, WI 53715 USA
DAMORE, PA
WAGNER, JA
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV WISCONSIN, WISCONSIN REG PRIMATE RES CTR, MADISON, WI 53715 USA
WAGNER, JA
[J].
NEURON,
1988,
1
(09)
: 783
-
790
[4]
NERVE GROWTH-FACTOR ACTION IS MEDIATED BY CYCLIC AMP- AND CA-+2 PHOSPHOLIPID-DEPENDENT PROTEIN-KINASES
CREMINS, J
论文数:
0
引用数:
0
h-index:
0
机构:
HARVARD UNIV,SCH MED,DEPT BIOL CHEM,BOSTON,MA 02115
CREMINS, J
WAGNER, JA
论文数:
0
引用数:
0
h-index:
0
机构:
HARVARD UNIV,SCH MED,DEPT BIOL CHEM,BOSTON,MA 02115
WAGNER, JA
HALEGOUA, S
论文数:
0
引用数:
0
h-index:
0
机构:
HARVARD UNIV,SCH MED,DEPT BIOL CHEM,BOSTON,MA 02115
HALEGOUA, S
[J].
JOURNAL OF CELL BIOLOGY,
1986,
103
(03)
: 887
-
893
[5]
SULFATED GLYCOSAMINOGLYCANS MODIFY GROWTH FACTOR-INDUCED NEURITE OUTGROWTH IN PC12 CELLS
DAMON, DH
论文数:
0
引用数:
0
h-index:
0
机构:
HARVARD UNIV, SCH MED, DANA FARBER CANC INST, DEPT BIOL CHEM & MOLEC PHARMACOL, BOSTON, MA 02115 USA
DAMON, DH
DAMORE, PA
论文数:
0
引用数:
0
h-index:
0
机构:
HARVARD UNIV, SCH MED, DANA FARBER CANC INST, DEPT BIOL CHEM & MOLEC PHARMACOL, BOSTON, MA 02115 USA
DAMORE, PA
WAGNER, JA
论文数:
0
引用数:
0
h-index:
0
机构:
HARVARD UNIV, SCH MED, DANA FARBER CANC INST, DEPT BIOL CHEM & MOLEC PHARMACOL, BOSTON, MA 02115 USA
WAGNER, JA
[J].
JOURNAL OF CELLULAR PHYSIOLOGY,
1988,
135
(02)
: 293
-
300
[6]
HEPARIN POTENTIATES THE ACTION OF ACIDIC FIBROBLAST GROWTH-FACTOR BY PROLONGING ITS BIOLOGICAL HALF-LIFE
DAMON, DH
论文数:
0
引用数:
0
h-index:
0
机构:
HARVARD UNIV,SCH MED,DANA FARBER CANC INST,DIV PEDIAT ONCOL,D910,44 BINNEY ST,BOSTON,MA 02115
DAMON, DH
LOBB, RR
论文数:
0
引用数:
0
h-index:
0
机构:
HARVARD UNIV,SCH MED,DANA FARBER CANC INST,DIV PEDIAT ONCOL,D910,44 BINNEY ST,BOSTON,MA 02115
LOBB, RR
DAMORE, PA
论文数:
0
引用数:
0
h-index:
0
机构:
HARVARD UNIV,SCH MED,DANA FARBER CANC INST,DIV PEDIAT ONCOL,D910,44 BINNEY ST,BOSTON,MA 02115
DAMORE, PA
WAGNER, JA
论文数:
0
引用数:
0
h-index:
0
机构:
HARVARD UNIV,SCH MED,DANA FARBER CANC INST,DIV PEDIAT ONCOL,D910,44 BINNEY ST,BOSTON,MA 02115
WAGNER, JA
[J].
JOURNAL OF CELLULAR PHYSIOLOGY,
1989,
138
(02)
: 221
-
226
[7]
ORNITHINE DECARBOXYLASE (EC4.1.1.17) ASSAY BASED UPON THE RETENTION OF PUTRESCINE BY A STRONG CATION-EXCHANGE PAPER
DJURHUUS, R
论文数:
0
引用数:
0
h-index:
0
DJURHUUS, R
[J].
ANALYTICAL BIOCHEMISTRY,
1981,
113
(02)
: 352
-
355
[8]
FOLKMAN J, 1988, AM J PATHOL, V130, P393
[9]
FIBROBLAST GROWTH-FACTOR
GOSPODAROWICZ, D
论文数:
0
引用数:
0
h-index:
0
GOSPODAROWICZ, D
NEUFELD, G
论文数:
0
引用数:
0
h-index:
0
NEUFELD, G
SCHWEIGERER, L
论文数:
0
引用数:
0
h-index:
0
SCHWEIGERER, L
[J].
MOLECULAR AND CELLULAR ENDOCRINOLOGY,
1986,
46
(03)
: 187
-
204
[10]
NERVE GROWTH-FACTOR MEDIATES PHOSPHORYLATION OF SPECIFIC PROTEINS
HALEGOUA, S
论文数:
0
引用数:
0
h-index:
0
HALEGOUA, S
PATRICK, J
论文数:
0
引用数:
0
h-index:
0
PATRICK, J
[J].
CELL,
1980,
22
(02)
: 571
-
581
←
1
2
3
→