LASER-INDUCED INVIVO FLUORESCENCE OF BACTERIOCHLORIN-A - PRELIMINARY-RESULTS

被引：10

作者：

SCHUITMAKER, JJ

VANLEENGOED, HLLM

VANDERVEEN, N

DUBBELMAN, TMAR

STAR, WM

机构：

[1] ACAD HOSP LEIDEN,DEPT OPHTHALMOL LAB,LEIDEN,NETHERLANDS

[2] DR DANIEL DEN HOED CANC CTR,ROTTERDAM,NETHERLANDS

[3] LEIDEN UNIV,DEPT MED BIOCHEM,2300 RA LEIDEN,NETHERLANDS

来源：

LASERS IN MEDICAL SCIENCE | 1993年 / 8卷 / 01期

关键词：

BACTERIOCHLORIN-A; FLUORESCENCE; INVIVO; IMAGING; LASER; PHOTOSENSITIZER; TUMOR;

D O I：

10.1007/BF02559754

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

Female WAG/RIJ rats with isologous RMA-mammary or rhabdomyosarcoma tumours transplanted subcutaneously on the flank and thigh were given 10 mg kg-1 bacteriochlorin a intravenously (IV). In vivo fluorescence properties of this new photosensitizer were studied in a first attempt by using intensified fluorescence imaging. Analysis of the digitized images yielded tumour/muscle fluorescence ratios. Thirty minutes after IV injection a ratio of about 2.4 was reached, which was maintained for at least 48 h. © 1993 Baillière Tindall.

引用

页码：39 / 42

页数：4

共 9 条

[1] PHOTOSENSITIZING PROPERTIES OF BACTERIOCHLOROPHYLLIN-A AND BACTERIOCHLORIN-A, 2 DERIVATIVES OF BACTERIOCHLOROPHYLL-A [J].