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DETECTION OF CELL-MEDIATED-IMMUNITY IN TYPE-I DIABETES-MELLITUS
被引:14
作者
:
CALCINARO, F
论文数:
0
引用数:
0
h-index:
0
机构:
CHILDRENS HOSP,DENVER,CO 80218
CHILDRENS HOSP,DENVER,CO 80218
CALCINARO, F
[
1
]
HAO, LM
论文数:
0
引用数:
0
h-index:
0
机构:
CHILDRENS HOSP,DENVER,CO 80218
CHILDRENS HOSP,DENVER,CO 80218
HAO, LM
[
1
]
CHASE, HP
论文数:
0
引用数:
0
h-index:
0
机构:
CHILDRENS HOSP,DENVER,CO 80218
CHILDRENS HOSP,DENVER,CO 80218
CHASE, HP
[
1
]
KLINGENSMITH, G
论文数:
0
引用数:
0
h-index:
0
机构:
CHILDRENS HOSP,DENVER,CO 80218
CHILDRENS HOSP,DENVER,CO 80218
KLINGENSMITH, G
[
1
]
LAFFERTY, KJ
论文数:
0
引用数:
0
h-index:
0
机构:
CHILDRENS HOSP,DENVER,CO 80218
CHILDRENS HOSP,DENVER,CO 80218
LAFFERTY, KJ
[
1
]
机构
:
[1]
CHILDRENS HOSP,DENVER,CO 80218
来源
:
JOURNAL OF AUTOIMMUNITY
|
1992年
/ 5卷
/ 02期
关键词
:
D O I
:
10.1016/0896-8411(92)90195-V
中图分类号
:
R392 [医学免疫学];
Q939.91 [免疫学];
学科分类号
:
100102 ;
摘要
:
Type I insulin dependent diabetes mellitus (IDDM) is thought to result from chronic, cell-mediated, 'autoimmune' islet damage. Antibody testing is extensively used to define and follow the pre-diabetic population. However, the assay for cell mediated immunity (CMI) should be more predictive of impending disease. This report shows that it is possible to detect human islet reactive CMI in the IDDM patient. Groups of athymic CD-1 nu/nu mice were injected intraperitoneally with either mononuclear blood cells (MBCs) or plasma from 10 newly diagnosed Type I diabetic patients and 10 normal control subjects. Both glycemic control and histopathology were used to assay islet specific CMI in diabetic individuals. None of the injected mice showed any impairment of glycemic control. However, MBCs from six of 10 diabetic patients, but from none of the 10 normal subjects, induced significant mononuclear cell infiltrate in the pancreas of the recipient mice (P=0.005). The infiltrate was focused on the islet tissue and no damage was seen in control tissues. No histological abnormalities were observed when plasma was transferred. We conclude that cellular reactivity seen in this model is tissue specific and disease associated. Our findings provide evidence that CMI to human islet tissue can be detected in IDDM patients. © 1992.
引用
收藏
页码:137 / 147
页数:11
相关论文
共 33 条
[1]
ARE INSULIN AUTOANTIBODIES MARKERS FOR INSULIN-DEPENDENT DIABETES-MELLITUS
ATKINSON, MA
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV FLORIDA,J HILLIS MILLER HLTH CTR,COLL MED,DEPT PATHOL,BOX J-275,GAINESVILLE,FL 32610
ATKINSON, MA
MACLAREN, NK
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV FLORIDA,J HILLIS MILLER HLTH CTR,COLL MED,DEPT PATHOL,BOX J-275,GAINESVILLE,FL 32610
MACLAREN, NK
RILEY, WJ
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV FLORIDA,J HILLIS MILLER HLTH CTR,COLL MED,DEPT PATHOL,BOX J-275,GAINESVILLE,FL 32610
RILEY, WJ
WINTER, WE
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV FLORIDA,J HILLIS MILLER HLTH CTR,COLL MED,DEPT PATHOL,BOX J-275,GAINESVILLE,FL 32610
WINTER, WE
FISK, DD
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV FLORIDA,J HILLIS MILLER HLTH CTR,COLL MED,DEPT PATHOL,BOX J-275,GAINESVILLE,FL 32610
FISK, DD
SPILLAR, RP
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV FLORIDA,J HILLIS MILLER HLTH CTR,COLL MED,DEPT PATHOL,BOX J-275,GAINESVILLE,FL 32610
SPILLAR, RP
[J].
DIABETES,
1986,
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IMMUNOLOGY AND DIABETES WORKSHOP - REPORT ON THE 3RD INTERNATIONAL (STAGE-3) WORKSHOP ON THE STANDARDIZATION OF CYTOPLASMIC ISLET CELL ANTIBODIES HELD IN NEW-YORK, NEW-YORK, OCTOBER 1987
BOITARD, C
论文数:
0
引用数:
0
h-index:
0
BOITARD, C
BONIFACIO, E
论文数:
0
引用数:
0
h-index:
0
BONIFACIO, E
BOTTAZZO, GF
论文数:
0
引用数:
0
h-index:
0
BOTTAZZO, GF
GLEICHMANN, H
论文数:
0
引用数:
0
h-index:
0
GLEICHMANN, H
MOLENAAR, J
论文数:
0
引用数:
0
h-index:
0
MOLENAAR, J
[J].
DIABETOLOGIA,
1988,
31
(07)
: 451
-
452
[3]
INSITU CHARACTERIZATION OF AUTOIMMUNE PHENOMENA AND EXPRESSION OF HLA MOLECULES IN THE PANCREAS IN DIABETIC INSULITIS
BOTTAZZO, GF
论文数:
0
引用数:
0
h-index:
0
机构:
ST BARTHOLOMEWS HOSP,SCH MED,DEPT DIABET & IMMUNOGENET,LONDON EC1A 7BE,ENGLAND
BOTTAZZO, GF
DEAN, BM
论文数:
0
引用数:
0
h-index:
0
机构:
ST BARTHOLOMEWS HOSP,SCH MED,DEPT DIABET & IMMUNOGENET,LONDON EC1A 7BE,ENGLAND
DEAN, BM
MCNALLY, JM
论文数:
0
引用数:
0
h-index:
0
机构:
ST BARTHOLOMEWS HOSP,SCH MED,DEPT DIABET & IMMUNOGENET,LONDON EC1A 7BE,ENGLAND
MCNALLY, JM
MACKAY, EH
论文数:
0
引用数:
0
h-index:
0
机构:
ST BARTHOLOMEWS HOSP,SCH MED,DEPT DIABET & IMMUNOGENET,LONDON EC1A 7BE,ENGLAND
MACKAY, EH
SWIFT, PGF
论文数:
0
引用数:
0
h-index:
0
机构:
ST BARTHOLOMEWS HOSP,SCH MED,DEPT DIABET & IMMUNOGENET,LONDON EC1A 7BE,ENGLAND
SWIFT, PGF
GAMBLE, DR
论文数:
0
引用数:
0
h-index:
0
机构:
ST BARTHOLOMEWS HOSP,SCH MED,DEPT DIABET & IMMUNOGENET,LONDON EC1A 7BE,ENGLAND
GAMBLE, DR
[J].
NEW ENGLAND JOURNAL OF MEDICINE,
1985,
313
(06)
: 353
-
360
[4]
ISLET-CELL ANTIBODIES IN DIABETES-MELLITUS WITH AUTOIMMUNE POLY-ENDOCRINE DEFICIENCIES
BOTTAZZO, GF
论文数:
0
引用数:
0
h-index:
0
机构:
MIDDLESEX HOSP, MED SCH, DEPT IMMUNOL, LONDON W1P 9PG, ENGLAND
MIDDLESEX HOSP, MED SCH, DEPT IMMUNOL, LONDON W1P 9PG, ENGLAND
BOTTAZZO, GF
FLORINCH.A
论文数:
0
引用数:
0
h-index:
0
机构:
MIDDLESEX HOSP, MED SCH, DEPT IMMUNOL, LONDON W1P 9PG, ENGLAND
MIDDLESEX HOSP, MED SCH, DEPT IMMUNOL, LONDON W1P 9PG, ENGLAND
FLORINCH.A
DONIACH, D
论文数:
0
引用数:
0
h-index:
0
机构:
MIDDLESEX HOSP, MED SCH, DEPT IMMUNOL, LONDON W1P 9PG, ENGLAND
MIDDLESEX HOSP, MED SCH, DEPT IMMUNOL, LONDON W1P 9PG, ENGLAND
DONIACH, D
[J].
LANCET,
1974,
2
(7892)
: 1279
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1283
[5]
BOYUM A, 1968, SCAND J CLIN LAB INV, VS 21, P77
[6]
BUSCHARD K, 1978, LANCET, V1, P908
[7]
EISENBARTH GS, 1986, NEW ENGL J MED, V314, P1360
[8]
PROGRESS TOWARD STANDARDIZATION OF CYTOPLASMIC ISLET CELL ANTIBODY-ASSAY
GLEICHMANN, H
论文数:
0
引用数:
0
h-index:
0
机构:
MIDDLESEX HOSP,DEPT IMMUNOL,LONDON W1,ENGLAND
MIDDLESEX HOSP,DEPT IMMUNOL,LONDON W1,ENGLAND
GLEICHMANN, H
BOTTAZZO, GF
论文数:
0
引用数:
0
h-index:
0
机构:
MIDDLESEX HOSP,DEPT IMMUNOL,LONDON W1,ENGLAND
MIDDLESEX HOSP,DEPT IMMUNOL,LONDON W1,ENGLAND
BOTTAZZO, GF
[J].
DIABETES,
1987,
36
(05)
: 578
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584
[9]
CAN FUTURE TYPE-1 DIABETES BE PREDICTED QUESTIONABLE - A STUDY IN FAMILIES OF AFFECTED CHILDREN
GORSUCH, AN
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0
引用数:
0
h-index:
0
机构:
ST BARTHOLOMEWS HOSP,COLL MED,DEPT DIABET & IMMUNOGENET,LONDON EC1A 7BE,ENGLAND
ST BARTHOLOMEWS HOSP,COLL MED,DEPT DIABET & IMMUNOGENET,LONDON EC1A 7BE,ENGLAND
GORSUCH, AN
SPENCER, KM
论文数:
0
引用数:
0
h-index:
0
机构:
ST BARTHOLOMEWS HOSP,COLL MED,DEPT DIABET & IMMUNOGENET,LONDON EC1A 7BE,ENGLAND
ST BARTHOLOMEWS HOSP,COLL MED,DEPT DIABET & IMMUNOGENET,LONDON EC1A 7BE,ENGLAND
SPENCER, KM
LISTER, J
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0
引用数:
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h-index:
0
机构:
ST BARTHOLOMEWS HOSP,COLL MED,DEPT DIABET & IMMUNOGENET,LONDON EC1A 7BE,ENGLAND
ST BARTHOLOMEWS HOSP,COLL MED,DEPT DIABET & IMMUNOGENET,LONDON EC1A 7BE,ENGLAND
LISTER, J
WOLF, E
论文数:
0
引用数:
0
h-index:
0
机构:
ST BARTHOLOMEWS HOSP,COLL MED,DEPT DIABET & IMMUNOGENET,LONDON EC1A 7BE,ENGLAND
ST BARTHOLOMEWS HOSP,COLL MED,DEPT DIABET & IMMUNOGENET,LONDON EC1A 7BE,ENGLAND
WOLF, E
BOTTAZZO, GF
论文数:
0
引用数:
0
h-index:
0
机构:
ST BARTHOLOMEWS HOSP,COLL MED,DEPT DIABET & IMMUNOGENET,LONDON EC1A 7BE,ENGLAND
ST BARTHOLOMEWS HOSP,COLL MED,DEPT DIABET & IMMUNOGENET,LONDON EC1A 7BE,ENGLAND
BOTTAZZO, GF
CUDWORTH, AG
论文数:
0
引用数:
0
h-index:
0
机构:
ST BARTHOLOMEWS HOSP,COLL MED,DEPT DIABET & IMMUNOGENET,LONDON EC1A 7BE,ENGLAND
ST BARTHOLOMEWS HOSP,COLL MED,DEPT DIABET & IMMUNOGENET,LONDON EC1A 7BE,ENGLAND
CUDWORTH, AG
[J].
DIABETES,
1982,
31
(10)
: 862
-
866
[10]
COMPARISON OF CYTOKINE EFFECTS ON MOUSE PANCREATIC ALPHA-CELL AND BETA-CELL LINES - VIABILITY, SECRETORY FUNCTION, AND MHC ANTIGEN EXPRESSION
HAMAGUCHI, K
论文数:
0
引用数:
0
h-index:
0
机构:
JACKSON LAB,BAR HARBOR,ME 04609
JACKSON LAB,BAR HARBOR,ME 04609
HAMAGUCHI, K
LEITER, EH
论文数:
0
引用数:
0
h-index:
0
机构:
JACKSON LAB,BAR HARBOR,ME 04609
JACKSON LAB,BAR HARBOR,ME 04609
LEITER, EH
[J].
DIABETES,
1990,
39
(04)
: 415
-
425
←
1
2
3
4
→
共 33 条
[1]
ARE INSULIN AUTOANTIBODIES MARKERS FOR INSULIN-DEPENDENT DIABETES-MELLITUS
ATKINSON, MA
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV FLORIDA,J HILLIS MILLER HLTH CTR,COLL MED,DEPT PATHOL,BOX J-275,GAINESVILLE,FL 32610
ATKINSON, MA
MACLAREN, NK
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV FLORIDA,J HILLIS MILLER HLTH CTR,COLL MED,DEPT PATHOL,BOX J-275,GAINESVILLE,FL 32610
MACLAREN, NK
RILEY, WJ
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV FLORIDA,J HILLIS MILLER HLTH CTR,COLL MED,DEPT PATHOL,BOX J-275,GAINESVILLE,FL 32610
RILEY, WJ
WINTER, WE
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV FLORIDA,J HILLIS MILLER HLTH CTR,COLL MED,DEPT PATHOL,BOX J-275,GAINESVILLE,FL 32610
WINTER, WE
FISK, DD
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV FLORIDA,J HILLIS MILLER HLTH CTR,COLL MED,DEPT PATHOL,BOX J-275,GAINESVILLE,FL 32610
FISK, DD
SPILLAR, RP
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV FLORIDA,J HILLIS MILLER HLTH CTR,COLL MED,DEPT PATHOL,BOX J-275,GAINESVILLE,FL 32610
SPILLAR, RP
[J].
DIABETES,
1986,
35
(08)
: 894
-
898
[2]
IMMUNOLOGY AND DIABETES WORKSHOP - REPORT ON THE 3RD INTERNATIONAL (STAGE-3) WORKSHOP ON THE STANDARDIZATION OF CYTOPLASMIC ISLET CELL ANTIBODIES HELD IN NEW-YORK, NEW-YORK, OCTOBER 1987
BOITARD, C
论文数:
0
引用数:
0
h-index:
0
BOITARD, C
BONIFACIO, E
论文数:
0
引用数:
0
h-index:
0
BONIFACIO, E
BOTTAZZO, GF
论文数:
0
引用数:
0
h-index:
0
BOTTAZZO, GF
GLEICHMANN, H
论文数:
0
引用数:
0
h-index:
0
GLEICHMANN, H
MOLENAAR, J
论文数:
0
引用数:
0
h-index:
0
MOLENAAR, J
[J].
DIABETOLOGIA,
1988,
31
(07)
: 451
-
452
[3]
INSITU CHARACTERIZATION OF AUTOIMMUNE PHENOMENA AND EXPRESSION OF HLA MOLECULES IN THE PANCREAS IN DIABETIC INSULITIS
BOTTAZZO, GF
论文数:
0
引用数:
0
h-index:
0
机构:
ST BARTHOLOMEWS HOSP,SCH MED,DEPT DIABET & IMMUNOGENET,LONDON EC1A 7BE,ENGLAND
BOTTAZZO, GF
DEAN, BM
论文数:
0
引用数:
0
h-index:
0
机构:
ST BARTHOLOMEWS HOSP,SCH MED,DEPT DIABET & IMMUNOGENET,LONDON EC1A 7BE,ENGLAND
DEAN, BM
MCNALLY, JM
论文数:
0
引用数:
0
h-index:
0
机构:
ST BARTHOLOMEWS HOSP,SCH MED,DEPT DIABET & IMMUNOGENET,LONDON EC1A 7BE,ENGLAND
MCNALLY, JM
MACKAY, EH
论文数:
0
引用数:
0
h-index:
0
机构:
ST BARTHOLOMEWS HOSP,SCH MED,DEPT DIABET & IMMUNOGENET,LONDON EC1A 7BE,ENGLAND
MACKAY, EH
SWIFT, PGF
论文数:
0
引用数:
0
h-index:
0
机构:
ST BARTHOLOMEWS HOSP,SCH MED,DEPT DIABET & IMMUNOGENET,LONDON EC1A 7BE,ENGLAND
SWIFT, PGF
GAMBLE, DR
论文数:
0
引用数:
0
h-index:
0
机构:
ST BARTHOLOMEWS HOSP,SCH MED,DEPT DIABET & IMMUNOGENET,LONDON EC1A 7BE,ENGLAND
GAMBLE, DR
[J].
NEW ENGLAND JOURNAL OF MEDICINE,
1985,
313
(06)
: 353
-
360
[4]
ISLET-CELL ANTIBODIES IN DIABETES-MELLITUS WITH AUTOIMMUNE POLY-ENDOCRINE DEFICIENCIES
BOTTAZZO, GF
论文数:
0
引用数:
0
h-index:
0
机构:
MIDDLESEX HOSP, MED SCH, DEPT IMMUNOL, LONDON W1P 9PG, ENGLAND
MIDDLESEX HOSP, MED SCH, DEPT IMMUNOL, LONDON W1P 9PG, ENGLAND
BOTTAZZO, GF
FLORINCH.A
论文数:
0
引用数:
0
h-index:
0
机构:
MIDDLESEX HOSP, MED SCH, DEPT IMMUNOL, LONDON W1P 9PG, ENGLAND
MIDDLESEX HOSP, MED SCH, DEPT IMMUNOL, LONDON W1P 9PG, ENGLAND
FLORINCH.A
DONIACH, D
论文数:
0
引用数:
0
h-index:
0
机构:
MIDDLESEX HOSP, MED SCH, DEPT IMMUNOL, LONDON W1P 9PG, ENGLAND
MIDDLESEX HOSP, MED SCH, DEPT IMMUNOL, LONDON W1P 9PG, ENGLAND
DONIACH, D
[J].
LANCET,
1974,
2
(7892)
: 1279
-
1283
[5]
BOYUM A, 1968, SCAND J CLIN LAB INV, VS 21, P77
[6]
BUSCHARD K, 1978, LANCET, V1, P908
[7]
EISENBARTH GS, 1986, NEW ENGL J MED, V314, P1360
[8]
PROGRESS TOWARD STANDARDIZATION OF CYTOPLASMIC ISLET CELL ANTIBODY-ASSAY
GLEICHMANN, H
论文数:
0
引用数:
0
h-index:
0
机构:
MIDDLESEX HOSP,DEPT IMMUNOL,LONDON W1,ENGLAND
MIDDLESEX HOSP,DEPT IMMUNOL,LONDON W1,ENGLAND
GLEICHMANN, H
BOTTAZZO, GF
论文数:
0
引用数:
0
h-index:
0
机构:
MIDDLESEX HOSP,DEPT IMMUNOL,LONDON W1,ENGLAND
MIDDLESEX HOSP,DEPT IMMUNOL,LONDON W1,ENGLAND
BOTTAZZO, GF
[J].
DIABETES,
1987,
36
(05)
: 578
-
584
[9]
CAN FUTURE TYPE-1 DIABETES BE PREDICTED QUESTIONABLE - A STUDY IN FAMILIES OF AFFECTED CHILDREN
GORSUCH, AN
论文数:
0
引用数:
0
h-index:
0
机构:
ST BARTHOLOMEWS HOSP,COLL MED,DEPT DIABET & IMMUNOGENET,LONDON EC1A 7BE,ENGLAND
ST BARTHOLOMEWS HOSP,COLL MED,DEPT DIABET & IMMUNOGENET,LONDON EC1A 7BE,ENGLAND
GORSUCH, AN
SPENCER, KM
论文数:
0
引用数:
0
h-index:
0
机构:
ST BARTHOLOMEWS HOSP,COLL MED,DEPT DIABET & IMMUNOGENET,LONDON EC1A 7BE,ENGLAND
ST BARTHOLOMEWS HOSP,COLL MED,DEPT DIABET & IMMUNOGENET,LONDON EC1A 7BE,ENGLAND
SPENCER, KM
LISTER, J
论文数:
0
引用数:
0
h-index:
0
机构:
ST BARTHOLOMEWS HOSP,COLL MED,DEPT DIABET & IMMUNOGENET,LONDON EC1A 7BE,ENGLAND
ST BARTHOLOMEWS HOSP,COLL MED,DEPT DIABET & IMMUNOGENET,LONDON EC1A 7BE,ENGLAND
LISTER, J
WOLF, E
论文数:
0
引用数:
0
h-index:
0
机构:
ST BARTHOLOMEWS HOSP,COLL MED,DEPT DIABET & IMMUNOGENET,LONDON EC1A 7BE,ENGLAND
ST BARTHOLOMEWS HOSP,COLL MED,DEPT DIABET & IMMUNOGENET,LONDON EC1A 7BE,ENGLAND
WOLF, E
BOTTAZZO, GF
论文数:
0
引用数:
0
h-index:
0
机构:
ST BARTHOLOMEWS HOSP,COLL MED,DEPT DIABET & IMMUNOGENET,LONDON EC1A 7BE,ENGLAND
ST BARTHOLOMEWS HOSP,COLL MED,DEPT DIABET & IMMUNOGENET,LONDON EC1A 7BE,ENGLAND
BOTTAZZO, GF
CUDWORTH, AG
论文数:
0
引用数:
0
h-index:
0
机构:
ST BARTHOLOMEWS HOSP,COLL MED,DEPT DIABET & IMMUNOGENET,LONDON EC1A 7BE,ENGLAND
ST BARTHOLOMEWS HOSP,COLL MED,DEPT DIABET & IMMUNOGENET,LONDON EC1A 7BE,ENGLAND
CUDWORTH, AG
[J].
DIABETES,
1982,
31
(10)
: 862
-
866
[10]
COMPARISON OF CYTOKINE EFFECTS ON MOUSE PANCREATIC ALPHA-CELL AND BETA-CELL LINES - VIABILITY, SECRETORY FUNCTION, AND MHC ANTIGEN EXPRESSION
HAMAGUCHI, K
论文数:
0
引用数:
0
h-index:
0
机构:
JACKSON LAB,BAR HARBOR,ME 04609
JACKSON LAB,BAR HARBOR,ME 04609
HAMAGUCHI, K
LEITER, EH
论文数:
0
引用数:
0
h-index:
0
机构:
JACKSON LAB,BAR HARBOR,ME 04609
JACKSON LAB,BAR HARBOR,ME 04609
LEITER, EH
[J].
DIABETES,
1990,
39
(04)
: 415
-
425
←
1
2
3
4
→