THE REGIOSELECTIVE SYNTHESIS OF ENANTIOMERICALLY PURE MYOINOSITOL DERIVATIVES - EFFICIENT SYNTHESIS OF MYOINOSITOL 1,4,5-TRISPHOSPHATE

被引：24

作者：

AGUILO, A ^{[1
]}

MARTINLOMAS, M ^{[1
]}

PENADES, S ^{[1
]}

机构：

[1] CSIC,INST QUIM ORGAN,JUAN DE LA CIERVA 3,E-28006 MADRID,SPAIN

来源：

TETRAHEDRON LETTERS | 1992年 / 33卷 / 03期

关键词：

D O I：

10.1016/S0040-4039(00)74142-6

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Regioselective 1-O-acylation of myo-inositol and simultaneous optical resolution has been achieved by perborylation, transmetallation using di-n-butyltin-bis-acetylacetonate and then acylation with (-)-menthyl chloroformate. Diastereomerically pure 1-O-(-)-menthoxycarbonyl-myo-inositol 1 can be used as starting material for the preparation of biologically important myo-inositol phosphates and glycosyl phosphatidylinositols in a shorter and effective way.

引用

页码：401 / 404

页数：4

共 17 条

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