AGE-DEPENDENT DECLINE IN COGNITIVE INFORMATION-PROCESSING OF HIV-POSITIVE INDIVIDUALS DETECTED BY EVENT-RELATED POTENTIAL RECORDINGS

被引：17

作者：

ARENDT, G ^{[1
]}

HEFTER, H ^{[1
]}

NELLES, HW ^{[1
]}

HILPERATH, F ^{[1
]}

STROHMEYER, G ^{[1
]}

机构：

[1] UNIV DUSSELDORF,DEPT MED,W-4000 DUSSELDORF 1,GERMANY

来源：

JOURNAL OF THE NEUROLOGICAL SCIENCES | 1993年 / 115卷 / 02期

关键词：

HIV INFECTION; EVENT-RELATED POTENTIAL; SLOWING OF COGNITIVE PROCESSES;

D O I：

10.1016/0022-510X(93)90229-R

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Cognitive event-related potentials (ERP) were recorded in 100 HIV-positive patients of all CDC stages without clinical CNS deficits with an auditory oddball paradigm. Four latency peaks and three amplitudes were evaluated (N1, P2, N2 and P3 latencies, N1-P2, P2-N2 and N2-P3 amplitudes). In contrast to an age-matched control group of comparable education and social environment, a statistically significant N2-P3 amplitude reduction was found in the patient group deteriorating with the CDC stages. The physiological N2-P3 amplitude reduction with age in normals was found to be twice as fast in HIV-positive individuals. No group-statistically relevant EEG abnormalities were found in the patient group. In psychometric testing, there was no marked depressive syndrome in the HIV-positive individuals, but a mild slowing of speed-dependent abilities.

引用

页码：223 / 229

页数：7

共 15 条

[1] MOTOR DYSFUNCTION IN HIV-INFECTED PATIENTS WITHOUT CLINICALLY DETECTABLE CENTRAL-NERVOUS DEFICIT [J].