INCREASED NUMBERS OF TH2-LIKE CD4+T CELLS IN TARGET ORGANS AND IN THE ALLERGEN-SPECIFIC REPERTOIRE OF ALLERGIC PATIENTS - POSSIBLE ROLE OF IL-4 PRODUCED BY NON-T-CELLS

被引：34

作者：

ROMAGNANI, S ^{[1
]}

MAGGI, E ^{[1
]}

PARRONCHI, P ^{[1
]}

MACCHIA, D ^{[1
]}

PICCINNI, MP ^{[1
]}

RICCI, M ^{[1
]}

机构：

[1] UNIV FLORENCE,DIV CLIN IMMUNOL & ALLERGOC,I-50121 FLORENCE,ITALY

来源：

INTERNATIONAL ARCHIVES OF ALLERGY AND APPLIED IMMUNOLOGY | 1991年 / 94卷 / 1-4期

关键词：

D O I：

10.1159/000235344

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

Phytohemagglutinin (PHA)-induced human T cell clones (TCC) derived from conjunctival flogistic tissues of 3 patients with vernal conjunctivitis produced unusually high amounts of interleukin-4 (IL-4) and no, or limited amounts of, gamma-interferon (IFN-gamma). Allergen (Dermatophagoides pteronyssinus or Lolium perenne group I)-specific TCC derived from peripheral blood of two atopic donors produced significantly higher amounts of IL-4 and significantly lower amounts of IFN-gamma than TCC specific for bacterial antigens (tetanus toxoid and PPD) contemporarily established from the same donors. These data provide evidence for a compartimentalization of Th2-like helper T cells in target organs and in the allergen-specific T cell repertoire of allergic patients. Non-B, non-T bone marrow cells could produce IL-4, but not IL-2 or IFN-gamma, in response to cross-linkage of Fc-epsilon type I receptors. These cells may further contribute to the maintenance and amplification of allergic inflammation.

引用

页码：133 / 136

页数：4

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