EFFECT OF ORAL CALCIUM SUPPLEMENTATION ON COLONIC CRYPT CELL-PROLIFERATION IN PATIENTS WITH ADENOMATOUS POLYPS OF THE LARGE-BOWEL

被引：27

作者：

OSULLIVAN, KR

MATHIAS, PM

BEATTIE, S

OMORAIN, C

机构：

[1] Meath and Adelaide Hospitals, Trinity College Medical School, Dublin

[2] Department of Biology, Dublin Institute of Technology, Dublin, Kevin Street

来源：

EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY | 1993年 / 5卷 / 02期

关键词：

CALCIUM; POLYPS; CELL PROLIFERATION; COLORECTAL CANCER;

D O I：

10.1097/00042737-199302000-00005

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Objective: To study the effect of oral calcium supplementation on colonic crypt cell proliferation in patients with adenomatous polyps of the large bowel. Patients: The study included 20 patients (polyp group); a further 10 patients with disease-free colons served as controls. Patients from the polyp group were randomly assigned to one of the two following groups: group 1 received 1g calcium daily for 1 month and group 2 received 2g calcium daily for 1 month. Methods: Colonoscopic biopsies were performed before and after calcium supplementation. Cell proliferation was analysed using the monoclonal antibody to bromodeoxyuridine technique. Results: The mean number of labelled cells as a ratio of total crypt cells (Ll%) and their relative positions within the crypt were determined. Both calcium doses were found to reduce total Ll%. However, 2g calcium appeared to reduce proliferation profiles to those seen in normal colonic crypts. Conclusion: The findings of this study suggest that oral calcium may be a preventive treatment for those at risk of developing colorectal cancer.

引用

页码：85 / 89

页数：5

共 21 条

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