HLA-B8,DR3 PHENOTYPE AND THE ANTIBODY-RESPONSE AGAINST EPSTEIN-BARR-VIRUS

被引：6

作者：

CARUSO, C ^{[1
]}

CANDORE, G ^{[1
]}

COLUCCI, AT ^{[1
]}

CIGNA, D ^{[1
]}

SAMMARTANO, F ^{[1
]}

AMMATUNA, P ^{[1
]}

机构：

[1] UNIV PALERMO,DIPARTIMENTO IGIENE & MICROBIOL,I-90134 PALERMO,ITALY

来源：

IMMUNOLOGICAL INVESTIGATIONS | 1993年 / 22卷 / 01期

关键词：

D O I：

10.3109/08820139309066192

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Antibodies against the viral capsid antigen (VCA) and nuclear antigens (EBNAs) of the Epstein-Barr virus (EBV) were determined in a sample of Sicilian population. A significant correlation was observed between HLA-BB,DR3 phenotype and reduced titres of antibodies to EBNAs, whereas HLA-BB,DR3 positive individuals displayed levels of antibodies to VCA comparable to those of HLA-BB,DR3 negative ones. These results further strenghten the suggestion that HLA-BB,DR3 positive subjects are low responders and that the depth of immune response depends on on the fashion of antigenic challenge.

引用

页码：41 / 51

页数：11

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