CONVENIENT CHEMICAL SYNTHESIS OF CMP-N-ACETYLNEURAMINATE (CMP-NEU-5-AC)

被引：37

作者：

MARTIN, TJ ^{[1
]}

SCHMIDT, RR ^{[1
]}

机构：

[1] UNIV CONSTANCE,FAK CHEM,POSTFACH 5560,W-7750 CONSTANCE,GERMANY

来源：

TETRAHEDRON LETTERS | 1993年 / 34卷 / 11期

关键词：

D O I：

10.1016/S0040-4039(00)60773-6

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Reaction of sialyl phosphites 1 and 2 with dibenzyl phosphate and phenyl phosphate furnished without addition of a catalyst directly the corresponding sialyl phosphates 3 and 4, respectively, in good yields. Similarly, reaction of 1 with acetylated CMP 5 afforded exclusively beta-configurated acetylated CMP-Neu-5-Ac 6; which was readily transformed into natural sialyl donor CMP-Neu-5-Ac (7).

引用

页码：1765 / 1768

页数：4

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