HYPOTHALAMIC MODULATION OF NOCICEPTION AND REPRODUCTION IN CLUSTER HEADACHE .1. THERAPEUTIC TRIALS OF LEUPROLIDE

被引：24

作者：

NICOLODI, M

SICUTERI, F

POGGIONI, M

机构：

[1] Interuniversity Centre of Neurochemistry and Clinical Pharmacology of Idiopathic Headache, Institute of Internal Medicine, Florence University, Florence

来源：

CEPHALALGIA | 1993年 / 13卷 / 04期

关键词：

D O I：

10.1046/j.1468-2982.1993.1304253.x

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

A slow-release gonadotropin-releasing hormone (Gn-RH) analogue was administered to 30 males suffering from chronic cluster headache (CH) in a placebo-controlled study with the aim of enhancing neurotransmission in the pain-suppressing systems of the hypothalamus through a feedback action involving neuroendocrine functions too. A significant improvement in the severity of the pain occurred together with the expected lowering of the libido and serum levels of testosterone and luteinizing hormone. We postulate that the benefit of the Gn-RH analogue relates to an impairment of neuronal modulation in cluster headache.

引用

页码：253 / 257

页数：5

共 31 条

[1] REGION-SELECTIVE ACTIVATION OF BRAIN MONOAMINE SYNTHESIS BY SEXUAL-ACTIVITY IN THE MALE-RAT [J].

AHLENIUS, S ;

CARLSSON, A ;

HILLEGAART, V ;

HJORTH, S ;

LARSSON, K .

EUROPEAN JOURNAL OF PHARMACOLOGY, 1987, 144 (01) :77-82

[2]

ASKHENAZY I, 1990, FERTIL STERIL, V53, P738

[3] A COMPARISON OF THE SUPPRESSIVE EFFECTS OF TESTOSTERONE AND A POTENT NEW GONADOTROPIN-RELEASING HORMONE ANTAGONIST ON GONADOTROPIN AND INHIBIN LEVELS IN NORMAL MEN [J].

BAGATELL, CJ ;

MCLACHLAN, RI ;

DEKRETSER, DM ;

BURGER, HG ;

VALE, WW ;

RIVIER, JE ;

BREMNER, WJ .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1989, 69 (01) :43-48

[4] HORMONAL EFFECTS OF GONADOTROPIN-RELEASING HORMONE (GNRH) AGONIST IN THE HUMAN MALE .3. EFFECTS OF LONG-TERM COMBINED TREATMENT WITH GNRH AGONIST AND ANDROGEN [J].

BHASIN, S ;

HEBER, D ;

STEINER, BS ;

HANDELSMAN, DJ ;

SWERDLOFF, RS .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1985, 60 (05) :998-1003

[5]

DELBENE E, 1987, TRENDS CLUSTER HEADA, P313

[6] REDUCED TESTOSTERONE LEVELS IN CLUSTER HEADACHE - A STRESS-RELATED PHENOMENON [J].

FACCHINETTI, F ;

NAPPI, G ;

CICOLI, C ;

MICIELI, G ;

RUSPA, M ;

BONO, G ;

GENAZZANI, AR .

CEPHALALGIA, 1986, 6 (01) :29-34

[7]

GENAZZANI AR, 1988, PAIN REPRODUCTION, P15

[8] THE SEXUALLY DIMORPHIC REGION OF THE PREOPTIC AREA IN RATS CONTAINS DENSER OPIATE RECEPTOR-BINDING SITES IN FEMALES [J].

HAMMER, RP .

BRAIN RESEARCH, 1984, 308 (01) :172-176

[9]

HOFFMANN GH, 1989, RELATIONSHIP ENDOGEN, P125

[10]

KALRA PS, 1984, INT C SERIES, V682, P882

← 1 2 3 4 →