N-ACETYLCYSTEINE PROTECTS AGAINST AGE-RELATED DECLINE OF OXIDATIVE-PHOSPHORYLATION IN LIVER-MITOCHONDRIA

被引：71

作者：

MIQUEL, J

FERRANDIZ, ML

DEJUAN, E

SEVILA, I

MARTINEZ, M

机构：

[1] UNIV ALICANTE, FAC MED, INST NEUROSCI, E-03080 ALACANT, SPAIN

[2] UNIV VALENCIA, FAC FARM, DEPT FARMACOL, E-46010 VALENCIA, SPAIN

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY-ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY SECTION | 1995年 / 292卷 / 3-4期

关键词：

AGING; MITOCHONDRIA; N-ACETYLCYSTEINE; THIOL;

D O I：

10.1016/0926-6917(95)90041-1

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Since it has been proposed that oxygen radical inactivation of key enzymes plays a critical role in cell aging, we have investigated the effects of a thiolic free radical scavenger on the oxidative phosphorylation enzymes of liver mitochondria from female OF-1 mice. At 48 weeks of age a control group was fed standard food pellets and another group received pellets containing 0.3% (w/w) of N-acetylcysteine. A 24-week treatment resulted in a significant increase in the specific activities of complex I, IV and V in the hepatic mitochondria of the N-acetylcysteine-treated animals as compared to aged controls.

引用

页码：333 / 335

页数：3

共 15 条

[1] THE ANTIOXIDANT ACTION OF N-ACETYLCYSTEINE - ITS REACTION WITH HYDROGEN-PEROXIDE, HYDROXYL RADICAL, SUPEROXIDE, AND HYPOCHLOROUS ACID
ARUOMA, OI
HALLIWELL, B
HOEY, BM
BUTLER, J
[J]. FREE RADICAL BIOLOGY AND MEDICINE, 1989, 6 (06) : 593 - 597
[2] ANTIOXIDANT ACTIVITY AND OTHER MECHANISMS OF THIOLS INVOLVED IN CHEMOPREVENTION OF MUTATION AND CANCER
DEFLORA, S
IZZOTTI, A
DAGOSTINI, F
CESARONE, CF
[J]. AMERICAN JOURNAL OF MEDICINE, 1991, 91 : S122 - S130
[3] IMPAIRMENT OF MITOCHONDRIAL OXIDATIVE-PHOSPHORYLATION IN THE BRAIN OF AGED MICE
FERRANDIZ, ML
MARTINEZ, M
DEJUAN, E
DIEZ, A
BUSTOS, G
MIQUEL, J
[J]. BRAIN RESEARCH, 1994, 644 (02) : 335 - 338
[4] ROLE OF SULFHYDRYL GROUPS IN OXIDATIVE PHOSPHORYLATION AND ION TRANSPORT BY RAT LIVER MITOCHONDRIA
HAUGAARD, N
LEE, NH
KOSTRZEWA, R
HORN, RS
HAUGAARD, ES
[J]. BIOCHIMICA ET BIOPHYSICA ACTA, 1969, 172 (02) : 198 - +
[5] LOWRY OH, 1951, J BIOL CHEM, V193, P265
[6] FAVORABLE EFFECTS OF THE ANTIOXIDANTS SODIUM AND MAGNESIUM THIAZOLIDINE CARBOXYLATE ON THE VITALITY AND LIFE-SPAN OF DROSOPHILA AND MICE
MIQUEL, J
ECONOMOS, AC
[J]. EXPERIMENTAL GERONTOLOGY, 1979, 14 (05) : 279 - 285
[7] MIQUEL J, 1990, GLUTATHIONE METABOLI, P187
[8] MIQUEL J, 1984, INTERVENTION AGEING, P317
[9] OERIU S, 1965, J GERONTOL, V20, P417
[10] OLIVER CN, 1987, J BIOL CHEM, V262, P5488

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