TISSUE-REPAIR - A CRITICAL DETERMINANT IN CCL4 HEPATOTOXICITY

被引：3

作者：

CALABRESE, EJ

LEONARD, DA

BALDWIN, LA

机构：

[1] School of Public Health, University of Massachusetts, Amherst

来源：

ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY | 1994年 / 27卷 / 01期

关键词：

D O I：

10.1006/eesa.1994.1010

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

A single antimitotic dose of colchicine administered 24 hr after a single ip dose of CCl4 profoundly enhanced lethality in the adult Sprague-Dawley male rat from <10% to over greater than or equal to 70% within the next 24 hr. These findings suggest that disruption,of normal hepatic cellular repair processes is a critical factor affecting the outcome of CCl4 intoxication. (C) 1994 Academic Press, Inc.

引用

页码：105 / 106

页数：2

共 5 条

[1] PROTECTION FROM CCL4 TOXICITY BY PRESTIMULATION OF HEPATOCELLULAR REGENERATION IN PARTIALLY HEPATECTOMIZED GERBILS [J].

CAI, ZW ;

MEHENDALE, HM .

BIOCHEMICAL PHARMACOLOGY, 1991, 42 (03) :633-644

[2] ROLE OF HEPATOCELLULAR REGENERATION AND HEPATOLOBULAR HEALING IN THE FINAL OUTCOME OF LIVER-INJURY - A 2-STAGE MODEL OF TOXICITY [J].

MEHENDALE, HM .

BIOCHEMICAL PHARMACOLOGY, 1991, 42 (06) :1155-1162

[3] POTENTIATION OF HALOMETHANE HEPATOTOXICITY BY CHLORDECONE - A HYPOTHESIS FOR THE MECHANISM [J].

MEHENDALE, HM .

MEDICAL HYPOTHESES, 1990, 33 (04) :289-299

[4] COLCHICINE ANTIMITOSIS ABOLISHES CCL4 AUTOPROTECTION [J].

RAO, VC ;

MEHENDALE, HM .

TOXICOLOGIC PATHOLOGY, 1991, 19 (04) :597-606

[5]

Smejkalova J, 1988, Sb Ved Pr Lek Fak Karlovy Univerzity Hradci Kralove, V31, P387

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