A CLINICAL-TRIAL OF BETHANECHOL IN PATIENTS WITH XEROSTOMIA AFTER RADIATION-THERAPY - A PILOT-STUDY

被引：34

作者：

EPSTEIN, JB

BURCHELL, JL

EMERTON, S

LE, ND

SILVERMAN, S

机构：

[1] BRITISH COLUMBIA CANADA AGCY, MED DENT STAFF, VANCOUVER, BC, CANADA

[2] UNIV BRITISH COLUMBIA, SCH DENT, VANCOUVER V6T 1W5, BC, CANADA

[3] BRITISH COLUMBIA CANADA AGCY, DEPT DENT, VANCOUVER, BC, CANADA

[4] BRITISH COLUMBIA CANADA AGCY, DIV EPIDEMIOL BIOMETRY & OCCUPAT ONCOL, VANCOUVER, BC, CANADA

来源：

ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY AND ENDODONTOLOGY | 1994年 / 77卷 / 06期

关键词：

D O I：

10.1016/0030-4220(94)90320-4

中图分类号：

R78 [口腔科学];

学科分类号：

1003 ;

摘要：

The effects of bethanechol in the treatment of dry mouth were assessed in patients with xerostomia after radiation therapy to the head and neck. Bethanechol possesses muscarinic and nicotinic-cholinergic activity that likely accounts for its mode of action. Bethanechol (25 mg, three times daily) was not associated with significant side effects. Statistically significant increases in whole resting saliva (p = 0.003) and whole stimulated saliva (p = 0.001) were seen. In patients with pretreatment stimulated saliva volumes greater than resting saliva volumes, a positive response to subsequent use of the sialagogue was seen.

引用

页码：610 / 614

页数：5

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