A CONFORMATION-PREFERENCE POTENCY CORRELATION FOR GNRH ANALOGS - NMR EVIDENCE

被引：3

作者：

ANDERSEN, NH

HAMMEN, PK

机构：

[1] Department of Chemistry, University of Washington, Seattle

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1991年 / 1卷 / 05期

关键词：

D O I：

10.1016/S0960-894X(01)81039-8

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Unlike natural GnRH (which shows a random flexible conformation with a populated reverse turn at residues 3,4), napharelin adopts (in aqueous media containing hexafluoroisopropanol) a non-random conformation in the region of the putative pharmacophore, a type II' beta-turn at residues 5 --> 8.

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页码：263 / 266

页数：4

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