EVIDENCE FOR PRESYNAPTIC BETA-ADRENOCEPTOR STIMULATION 24 HOURS AFTER A 6 HOUR ADRENALINE INFUSION

被引：1

作者：

BACHMANN, AW ^{[1
]}

GORDON, RD ^{[1
]}

BALLANTINE, DM ^{[1
]}

机构：

[1] UNIV QUEENSLAND,GREENSLOPES HOSP,DEPT MED,ENDOCRINE HYPERTENS RES UNIT,BRISBANE,QLD 4120,AUSTRALIA

来源：

CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY | 1992年 / 19卷 / 05期

关键词：

ADRENALINE; ADRENALINE INFUSION; AMBULATORY BLOOD PRESSURE; NORADRENALINE; NORMAL SUBJECTS; PLASMA; URINE;

D O I：

10.1111/j.1440-1681.1992.tb00460.x

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

1. The effects of 6 h infusions of adrenaline (INF-A) and dextrose (INF-D) were compared in nine normal subjects. 2. A significant increase in systolic blood pressure was observed during INF-A compared with INF-D and, 24 h after infusion, diastolic blood pressure was higher after INF-A than after INF-D. 3. Heart rate (HR) was significantly higher during INF-A than during INF-D. 4. As expected, plasma ADR increased significantly during INF-A but, unexpectedly, remained elevated 60 min post infusion compared with INF-D. Levels during activity the next morning were somewhat higher after INF-A, but not significantly different from INF-D. 5. Plasma NA increased transiently during INF-A and decreased during INF-D. Urinary NA was significantly higher during INF-A than during INF-D, and insignificantly higher during overnight recumbency, consistent with enhanced noradrenergic transmission.

引用

页码：311 / 314

页数：4

共 14 条

[1]

ALDERGRASCHINSK.E, 1975, BRIT J PHARMACOL, V53, P43

[2] PHEOCHROMOCYTOMAS SECRETING ADRENALINE BUT NOT NORADRENALINE DO NOT CAUSE HYPERTENSION AND REQUIRE PRECISE ADRENALINE MEASUREMENT FOR DIAGNOSIS [J].