THE ABSORPTION SITE OF CYCLOSPORINE IN THE HUMAN GASTROINTESTINAL-TRACT

被引：129

作者：

DREWE, J

BEGLINGER, C

KISSEL, T

机构：

[1] UNIV BASEL, KANTONSSPITAL, DEPT RES, CH-4031 BASEL, SWITZERLAND

[2] UNIV BASEL, KANTONSSPITAL, DIV GASTROENTEROL, CH-4031 BASEL, SWITZERLAND

[3] UNIV MARBURG, DEPT PHARMACEUT, W-3550 MARBURG, GERMANY

来源：

BRITISH JOURNAL OF CLINICAL PHARMACOLOGY | 1992年 / 33卷 / 01期

关键词：

CYCLOSPORINE; LOCAL ADMINISTRATION; INTESTINAL ABSORPTION; HUMAN;

D O I：

10.1111/j.1365-2125.1992.tb03998.x

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

1 An emulsion preparation of cyclosporin was administered locally to different parts of the small and large intestine by gavage: to the duodenum (opposite to the papilla of Vater), jejunum (150 cm distal to the teeth), ileum (300 cm distal to the teeth), and to the colon descendens (30 cm proximal to the anus). 2 The bioavailability of cyclosporin after these instillations was compared with that after oral administration of a hard gelatine capsule formulation. 3 Cyclosporin was found to be absorbed predominantly in the small intestine. This may have implications for dosage in patients with reduced absorptive surface area.

引用

页码：39 / 43

页数：5

共 33 条

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