ALBUTEROL AEROSOL VERSUS ALBUTEROL ROTACAPS(R) IN EXERCISE-INDUCED BRONCHOSPASM IN CHILDREN

被引：7

作者：

BRONSKY, EA

SPECTOR, SL

PEARLMAN, DS

JUSTUS, SE

BISHOP, AL

机构：

[1] AAAA Medical Research Group, Salt Lake City, UT

[2] Allergy Medical Clinic, Los Angeles, CA

[3] Colorado Allergy and Asthma Clinic, PC, Aurora, CO

[4] Glaxo Research Institute, Research Triangle Park, NC

来源：

JOURNAL OF ASTHMA | 1995年 / 32卷 / 03期

关键词：

D O I：

10.3109/02770909509089509

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

The purpose of this study was to determine the safety and effectiveness of albuterol aerosol 180 mu g and albuterol powder 200 mu g in the prevention of exercise-induced bronchospasm in children. Forty-six patients aged 4-11 years with asthma and exercise-induced bronchospasm were enrolled in this randomized, double-blind, single-dose, three-way crossover study comparing albuterol aerosol, albuterol powder, and placebo. Exercise challenge was performed at the screening visit for qualifying and baseline determinations of pulmonary function and then 15 min after drug administration at each of three visits. Prevention of exercise-induced bronchospasm was assessed by comparing across all treatment groups the percentage change in FEV(1) from pre- to postexercise, the percentage of patients protected by treatment, postexercise minimum FEV(1), and postexercise change in FEV(1). Safety was assessed by observation of clinical adverse events, laboratory tests, physical examination, electrocardiogram and rhythm strips, vital signs, and pulmonary auscultation.

引用

页码：207 / 214

页数：8

共 19 条

[1]

Bronsky E., Bucholtz G.A., Busse W.W., Et al., Comparison of inhaled albuterol powder and aerosol in asthma, J Allergy Clin Immunol, 79, pp. 741-747, (1987)

[2]

von Berg A., Berdel D., Efficacy of formoterol metered aerosol in children, Lung, 168, pp. 90-98, (1990)

[3]

Henriksen J.M., Agertoft L., Pedersen S., Protective effect and duration of action of inhaled formoterol and salbutamol on exercise-induced asthma in children, J Allergy Clin Immunol, 89, pp. 1176-1182, (1992)

[4]

Henriksen J.M., Agertoft L., Pedersen S., Protective effect and duration of action of inhaled formoterol and salbutamol on exercise-induced asthma in children, Eur Respir J, 4, (1991)

[5]

Francis P.W., Krastins I.R., Levison H., Oral and inhaled salbutamol in the prevention of exercise-induced bronchospasm, Pediatrics, 66, pp. 103-108, (1980)

[6]

Polgar G., Promadhat V., Pulmonary Function Testing in Children, Techniques and Standards., (1971)

[7]

Eggleston P.A., Rosenthal R.R., Anderson S.A., Et al., Guidelines for the methodology of exercise challenge testing of asthmatics, J Allergy Clin Immunol, 64, 6 pt 2, pp. 642-645, (1979)

[8]

Gardner R.M., Standardization of spirometry: A summary of recommendations from the American Thoracic Society: The 1987 update, Ann Intern Med, 108, pp. 217-220, (1988)

[9]

Sly R.M., Puapan P., Ghazanshani S., Midha R., Exercise-induced bronchospasm: Evaluation of albuterol aerosol, Ann Allergy, 34, pp. 7-14, (1975)

[10]

Lenney W., Milner A.D., Hiller E.J., Use of salbutamol powder in childhood asthma, Arch Dis Child, 53, pp. 958-961, (1978)

← 1 2 →