IMPACT OF SITE RELEASE VAGINAL PH BUFFER CREAM ON INTROITAL COLONIZATION BY GRAM-NEGATIVE BACILLI

被引:4
作者
MOORMAN, CN
FOWLER, JE
机构
[1] UNIV MISSISSIPPI,MED CTR,DIV UROL,2500 N STATE ST,JACKSON,MS 39216
[2] UNIV ILLINOIS,COLL MED,CHICAGO,IL 60680
关键词
VAGINAL CREAMS; FOAMS AND JELLIES; VAGINAL DISEASES; BACTERIAL INFECTIONS; GRAM-NEGATIVE BACTERIA;
D O I
10.1016/S0022-5347(17)37631-0
中图分类号
R5 [内科学]; R69 [泌尿科学(泌尿生殖系疾病)];
学科分类号
1002 ; 100201 ;
摘要
Colonization of the vaginal introitus by gram-negative bacilli is a critical event in the pathogenesis of bacteriuria and is promoted by an abnormal pH elevation. To determine whether a pH reduction might inhibit colonization we conducted a placebo controlled, crossover study of a site release vaginal pH buffer cream. A total of 12 premenopausal women with a history of urinary tract infection participated in the 12-week investigation. The mean introital pH during application of the placebo and buffer was 4.87 and 4.61, respectively (p < 0.01). However, the percentage of positive introital cultures during application of the placebo and buffer (40.3 and 35.3, respectively) and the mean density of colonization (23,600 and 22,700 bacteria per ml., respectively) were not significantly different. The percentage of positive introital cultures and the mean colonization density were also not different during application of the placebo and buffer when the patients were retrospectively stratified as light and heavy colonizers. These data suggest that alteration of the introital pH within a range of 4.5 to 5.0 does not influence the growth of uropathogens on the vaginal mucosa.
引用
收藏
页码:1576 / 1578
页数:3
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