VASCULITIS AND ANTINEUTROPHIL CYTOPLASMIC AUTOANTIBODIES ASSOCIATED WITH PROPYLTHIOURACIL THERAPY

被引：282

作者：

DOLMAN, KM

GANS, ROB

VERVAAT, TJ

ZEVENBERGEN, G

MAINGAY, D

NIKKELS, RE

DONKER, AJM

BORNE, AEGKV

GOLDSCHMEDING, R

机构：

[1] NETHERLANDS RED CROSS, BLOOD TRANSFUS SERV,CENT LAB,PUBLICAT SECRETARIAT, POB 9406, 1006 AK AMSTERDAM, NETHERLANDS

[2] UNIV AMSTERDAM, EXPTL & CLIN IMMUNOL LAB, AMSTERDAM, NETHERLANDS

[3] FREE UNIV AMSTERDAM HOSP, DEPT NEPHROL, AMSTERDAM, NETHERLANDS

[4] ST LUCAS HOSP, DEPT INTERNAL MED, AMSTERDAM, NETHERLANDS

[5] WESTFIES GASTLUIS, DEPT INTERNAL MED, HOORN, NETHERLANDS

[6] GOOI NOORD HOSP, DEPT INTERNAL MED, BLARICUM, NETHERLANDS

[7] DE WEVER HOSP, DEPT INTERNAL MED, HEARTEN, NETHERLANDS

[8] UNIV AMSTERDAM, ACAD MED CTR, DEPT HEMATOL, 1105 AZ AMSTERDAM, NETHERLANDS

[9] UNIV AMSTERDAM, ACAD MED CTR, DEPT PATHOL, 1105 AZ AMSTERDAM, NETHERLANDS

来源：

LANCET | 1993年 / 342卷 / 8872期

关键词：

D O I：

10.1016/0140-6736(93)91761-A

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Vasculitis is a rare complication of propylthiouracil therapy. Antineutrophil cytoplasmic antibodies (ANCA) have been described in association with several vasculitic disorders. We report detection of ANCA against human neutrophil elastase, proteinase 3, and myeloperoxidase in serum from six patients who developed evidence of vasculitis during propylthiouracil treatment of hyperthyroidism. On withdrawal of the drug ANCA concentrations fell and clinical symptoms resolved completely.

引用

页码：651 / 652

页数：2

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