AMITRIPTYLINE INHIBITS STRIATAL EFFLUX OF NEUROTRANSMITTERS VIA BLOCKADE OF VOLTAGE-DEPENDENT NA+ CHANNELS

被引：26

作者：

ISHII, Y ^{[1
]}

SUMI, T ^{[1
]}

机构：

[1] TOKYO INST PSYCHIAT,DEPT PSYCHOPHARMACOL,2-1-8 KAMIKITAZAWA,SETAGAYA KU,TOKYO 156,JAPAN

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 1992年 / 221卷 / 2-3期

关键词：

AMITRIPTYLINE; NA+ CHANNELS; DOPAMINE; AMINO ACIDS; VERATRIDINE; STRIATAL SLICES;

D O I：

10.1016/0014-2999(92)90726-K

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Amitriptyline, a tricyclic antidepressant, almost completely inhibited veratridine- or scorpion toxin-evoked efflux of endogenous dopamine (DA) and gamma-aminobutyric acid (GABA) from rat striatal slices without any effects of 30 mM K+ or 4-aminopyridine on basal and evoked efflux. The effects of amitriptyline on glutamate efflux were comparable to those on DA or GABA efflux. These effects of amitriptyline can be well explained by its blockade of voltage-dependent Na+ channels and may be independent of other activities of this drug such as re-uptake inhibition of monoamines and blockade of K+ channels.

引用

页码：377 / 380

页数：4

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