PSEUDOMONAS-AERUGINOSA, MUCOIDY AND THE CHRONIC INFECTION PHENOTYPE IN CYSTIC-FIBROSIS

被引：97

作者：

DERETIC, V ^{[1
]}

SCHURR, MJ ^{[1
]}

YU, HW ^{[1
]}

机构：

[1] UNIV TEXAS, HLTH SCI CTR, DEPT MICROBIOL, SAN ANTONIO, TX 78284 USA

来源：

TRENDS IN MICROBIOLOGY | 1995年 / 3卷 / 09期

关键词：

D O I：

10.1016/S0966-842X(00)88974-X

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

During chronic infections in cystic fibrosis, persistence of Pseudomonas aeruginosa is associated with conversion into forms that are characterized by a mucoid colony morphology, rough lipopolysaccharide and, paradoxically, decreased systemic virulence. The mutations underlying these changes occur in global regulators, such as alternative sigma factors and their accessory elements.

引用

页码：351 / 356

页数：6

共 59 条

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