IDENTIFICATION OF A PROTEIN PRODUCT OF THE MYOTONIC-DYSTROPHY GENE USING PEPTIDE-SPECIFIC ANTIBODIES

被引：26

作者：

BREWSTER, BS

JEAL, S

STRONG, PN

机构：

[1] Hammersmith Hosp, Royal Postgrad Med Sch, Neuromuscular Unit, London, W12 0NN England, DU Cane Rd

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1993年 / 194卷 / 03期

关键词：

D O I：

10.1006/bbrc.1993.1958

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In order to identify the protein product of the recently characterised myotonic dystrophy gene, we have raised an antibody (DMAP1) to a peptide sequence of the predicted gene product. This antibody identifies a novel 52kDa protein in a range of mouse tissues, and in addition a related 42kDa protein in brain and heart. A second antibody raised to a different peptide from the same predicted sequence, also identities the 52kDa protein, which strongly implies that this 52kDa protein is a major translation product of the myotonic dystrophy gene. © 1993 Academic Press. All rights reserved.

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页码：1256 / 1260

页数：5

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