SYNTHESIS AND ANTITUMOR ACTIVITY OF 6-TRIFLUOROMETHYLCYCLOPHOSPHAMIDE AND RELATED COMPOUNDS

被引：18

作者：

FARMER, PB ^{[1
]}

COX, PJ ^{[1
]}

机构：

[1] ROY CANC HOSP,CHESTER BEATTY RES INST,LONDON SW3 6JB,ENGLAND

来源：

JOURNAL OF MEDICINAL CHEMISTRY | 1975年 / 18卷 / 11期

关键词：

D O I：

10.1021/jm00245a012

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

引用

页码：1106 / 1110

页数：5

共 17 条

[1] FORMATION OF CYTOTOXIC ALDEHYDE ACROLEIN DURING IN-VITRO DEGRADATION OF CYCLOPHOSPHAMIDE [J].

ALARCON, RA ;

MEIENHOF.J .

NATURE-NEW BIOLOGY, 1971, 233 (42) :250-&

[2]

ALARCON RA, 1972, CANCER RES, V32, P2519

[3]

ARNOLD H, 1961, ARZNEIMITTEL-FORSCH, V11, P143

[4] GE++ SYNTHESIS AND BREAKDOWN OF CYTOSTATICALLY ACTIVE N-PHOSPHAMIDE ESTERS OF THE BIS-(BETA-CHLORETHYL)-AMINE [J].

ARNOLD, H ;

BOURSEAUX, F .

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 1958, 70 (17-8) :539-544

[5] UNTERSUCHUNGEN AN DER P=N-DOPPELBINDUNG .3. GIBT ES PHOSPHORSAURE-AMID-IMIDE MIT PHOSPHOR(+5) DER KOORDINATIONSZAHL 3 [J].

BOCK, H ;

WIEGRABE, W .

CHEMISCHE BERICHTE-RECUEIL, 1966, 99 (02) :377-&

[6] OBSERVATIONS ON MECHANISM OF HYDROXYLATION OF CYCLOPHOSPHAMIDE BY RAT-LIVER MICROSOMES - METABOLISM OF CYCLOPHOSPHAMIDE-4-D2 [J].

CONNORS, TA ;

COX, PJ ;

FARMER, PB ;

FOSTER, AB ;

JARMAN, M ;

MACLEOD, JK .

BIOMEDICAL MASS SPECTROMETRY, 1974, 1 (02) :130-136

[7] SOME STUDIES OF ACTIVE INTERMEDIATES FORMED IN MICROSOMAL METABOLISM OF CYCLOPHOSPHAMIDE AND ISOPHOSPHAMIDE [J].

CONNORS, TA ;

COX, PJ ;

FARMER, PB ;

FOSTER, AB ;

JARMAN, M .

BIOCHEMICAL PHARMACOLOGY, 1974, 23 (01) :115-129

[8] NEW PLATINUM COMPLEXES WITH ANTITUMOR ACTIVITY [J].

CONNORS, TA ;

JONES, M ;

ROSS, WCJ ;

BRADDOCK, PD ;

KHOKHAR, AR ;

TOBE, ML .

CHEMICO-BIOLOGICAL INTERACTIONS, 1972, 5 (06) :415-424

[9] MICROSOMAL METABOLISM OF SOME ANALOGS OF CYCLOPHOSPHAMIDE - 4-METHYLCYCLOPHOSPHAMIDE [J].

COX, PJ ;

FARMER, PB ;

JARMAN, M .

BIOCHEMICAL PHARMACOLOGY, 1975, 24 (05) :599-606

[10] PREPARATION OF N-PHOSPHORYLATED DERIVATIVES OF BIS-BETA-CHLOROETHYLAMINE [J].

FRIEDMAN, OM ;

SELIGMAN, AM .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1954, 76 (03) :655-658

← 1 2 →