CONSERVATION OF ENGRAILED-LIKE HOMEOBOX SEQUENCES DURING VERTEBRATE EVOLUTION

被引：51

作者：

HOLLAND, PWH

WILLIAMS, NA

机构：

[1] Department of Zoology, University of Oxford, Oxford, 0X1 3PS, South Parks Road

来源：

FEBS LETTERS | 1990年 / 277卷 / 1-2期

关键词：

ENGRAILED; HOMEOBOX; PCR; MOLECULAR EVOLUTION; VERTEBRATE DEVELOPMENT;

D O I：

10.1016/0014-5793(90)80858-G

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The Drosophila melanogaster developmental gene engrailed (en) is a member of a distinct subfamily of homeobox genes with a wide phylogenetic distribution. Here we report the use of reduced stringency polymerase chain reaction (PCR) to amplify and clone 8 genes related to en from 5 vertebrate species, including representatives of the most ancient vertebrate lineages. Nucleotide and deduced amino acid sequence comparisons between mouse, toad, zebrafish, lamprey and hagfish genes reveal extensive evolutionary conservation, and suggests that 2 en-like genes have been retained in most vertebrate lineages.

引用

页码：250 / 252

页数：3

共 15 条

[1]

[Anonymous], 1986, MANIPULATING MOUSE E

[2]

DAVIDSON D, 1988, DEVELOPMENT, V104, P305

[3] EXPRESSION PATTERNS OF THE HOMEO BOX-CONTAINING GENES EN-1 AND EN-2 AND THE PROTO-ONCOGENE INT-1 DIVERGE DURING MOUSE DEVELOPMENT [J].