EFFECT OF NMDA AND 2-AMINO-7-PHOSPHONOHEPTANOATE FOCAL INJECTION INTO THE VENTROLATERAL THALAMIC NUCLEUS ON THE HIGH-PRESSURE NEUROLOGICAL SYNDROME IN THE RAT

被引：14

作者：

MILLAN, MH ^{[1
]}

WARDLEYSMITH, B ^{[1
]}

HALSEY, MJ ^{[1
]}

MELDRUM, BS ^{[1
]}

机构：

[1] NORTHWICK PK HOSP & CLIN RES CTR,CANC RES CAMPAIGN,DIV ANAESTHESIA,HARROW HA1 3UJ,MIDDX,ENGLAND

来源：

BRAIN RESEARCH | 1990年 / 507卷 / 02期

关键词：

2-Amino-7-phosphonoheptanoate; Convulsion; High pressure neurological syndrome; N-Methyl-d-aspartate; Thalamus; Tremor;

D O I：

10.1016/0006-8993(90)90298-P

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

We report the effect of focal injections of N-methyl-d-aspartate (NMDA, 5 nmol) and 2-amino-7-phosphonoheptanoate (APH, 5 and 10 nmol) into the ventrolateral thalamic nucleus on behavioural symptoms of the high pressure neurological syndrome in rats. The injection of NMDA significantly lowers the threshold pressure for tremor and increases its intensity. The injection of APH significantly increases the threshold pressure for tremor and decreases its intensity. APH, 10 nmol, significantly increases the threshold pressure for myoclonus and convulsions. These protective effects are, however, less pronounced than those produced by either systemic injection of APH or its focal infusion into the basal ganglia output system. © 1990.

引用

页码：354 / 356

页数：3

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