THE USE OF MIFEPRISTONE PRIOR TO PROSTAGLANDIN-INDUCED MIDTRIMESTER-ABORTION

被引：44

作者：

URQUHART, DR ^{[1
]}

TEMPLETON, AA ^{[1
]}

机构：

[1] UNIV ABERDEEN,DEPT OBSTET & GYNAECOL,ABERDEEN AB9 2ZD,SCOTLAND

来源：

HUMAN REPRODUCTION | 1990年 / 5卷 / 07期

关键词：

Mifepristone; Second trimester; Termination; Uterine activity;

D O I：

10.1093/oxfordjournals.humrep.a137203

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

It has previously been established that the administration of mifepristone prior to prostaglandin-induced second trimester termination of pregnancy significantly reduces the induction to abortion interval. In this study, mifepristone (600 mg) was administered 24, 36 and 48 h prior to extra-amniotic infusion of prostaglandin in an attempt to ehcidate the optimal time interval. There was a significant reduction in the induction to abortion interval, dose of prostaglandin required and attendant side effects in all three treated groups compared to controls. However, there was no significant difference among the treatment groups, despite evidence of increased uterine activity 36 h following mifepristone administration. No bleeding was observed prior to prostaglandin infusion in any of the groups and it is suggested that mifepristone could be administered safely prior to hospital admission for termination. © 1990 Oxford University Press.

引用

页码：883 / 886

页数：4

共 18 条

[1]

Csapom A.I., The prospects of prostaglandins in post conceptional therapy, Prostaglandins, 3, pp. 245-259, (1973)

[2]

Dubois C., Ulman A., Baulieu E.E., Contragestion with late luteal administration of RU486 (Mifepristone), Fertii Sterii, 50, pp. 593-659, (1988)

[3]

Elia D., Clinical study of RU486 in early pregnancy, The Antiprogestin Steroid RU4S6 and Human Fertility Control, pp. 211-220, (1985)

[4]

Embrey M.P., Hillier K., Mahcndren P., Induction of Abortion by Extra Amniotic Administration of Prostaglandin Ej and F2, pp. 146-149, (1972)

[5]

(1989)

[6]

Karim S., Filshie G.M., Therapeutic abortion using prostaglandin F2, Lancet, I, pp. 157-159, (1970)

[7]

Pattison N.S., Webster M.A., Phipps S.L., Erson A., Gillmer M., Inhibition of 3-0-hydroxy steroid dehydrogenase (3/3-HSD) activity in first and second trimester human pregnancy and the luteal phase using epostane, Fertil, Sterii, 42, pp. 875-881, (1985)

[8]

Philibert D., Deraedt R., Teutsch G., Toumemine C., Sakiz E., Ru486-A New Lead for Steroidal Antihormones, 64Th Annual Meeting of the Endocrine Society, (1982)

[9]

Radestad A., Christensen W.J., Stromberg L., Induced cervical ripening with mifepristone in first trimester abortion, Contraception, 38, pp. 301-312, (1988)

[10]

Rodger M.W., Baird D.T., Induction of therapeutic abortion in early pregnancy with mifepristone in combination with prostaglandin pessary, Lancet, Iit, pp. 1415-1418, (1987)

← 1 2 →