EFFECTS OF LEAD ON KINETICS OF H-3 DOPAMINE UPTAKE BY RAT-BRAIN SYNAPTOSOMES

被引：7

作者：

BOYKIN, MJ

CHETTY, CS

RAJANNA, B

机构：

[1] Division of Natural Sciences, Selma University, Selma

来源：

ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY | 1991年 / 22卷 / 01期

关键词：

D O I：

10.1016/0147-6513(91)90050-Y

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

The effects of lead on 3H-dopamine (3H-DA) uptake in rat brain synaptosomes were studied. Pb inhibited 3H-DA uptake in vitro and in vivo in a concentration-dependent manner. Altered pH versus 3H-DA uptake demonstrated comparable inhibition in buffered acidic, neutral, and alkaline pH ranges, and higher inhibition was observed in neutral pH. Kinetic studies of ATP activation of 3H-DA uptake indicated competitive inhibition by Pb. The inhibition of 3H-DA uptake followed the Na+ concentrations. The results indicate that the Pb inhibition of 3H-DA uptake is pH, ATP, and Na+ dependent. © 1991.

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页码：88 / 93

页数：6

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