ADDITIVITY OF NICOTINIC AND MUSCARINIC CHOLINERGIC STIMULATION OF SUBSTANTIA-NIGRA

被引：5

作者：

PARKER, GC ^{[1
]}

WINN, P ^{[1
]}

机构：

[1] UNIV ST ANDREWS,DEPT PSYCHOL,ST ANDREWS KY16 9JU,FIFE,SCOTLAND

来源：

NEUROREPORT | 1992年 / 3卷 / 12期

基金：

英国惠康基金;

关键词：

SUBSTANTIA-NIGRA; ACETYLCHOLINE; CARBACHOL; NICOTINE; MUSCARINIC RECEPTORS; NICOTINIC RECEPTORS; FEEDING BEHAVIOR;

D O I：

10.1097/00001756-199212000-00018

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

MICROINJECTION of cholinergic agonists into the anterior substantia nigra increases behaviours for which there is a pre-existing tendency and a low current rate. Rats received microinjections of carbachol, nicotine or a combination of both into the anterior substantia nigra. Carbachol and nicotine both stimulated consumption of palatable food in a dose-dependent manner (F(3,24) = 3.99, p < 0.02 and F(3,33) = 7.07, p < 0.01 respectively). Addition of carbachol to each dose of nicotine caused a significant increase in feeding compared with nicotine alone (F(1,23) = 7.01 ,p < 0.015). This suggests muscarinic or nicotinic cholinergic stimulation of the anterior substantia nigra can have behaviourally similar effects and, at the doses used here, the effects of nicotinic and muscarinic stimulation are additive.

引用

页码：1105 / 1108

页数：4

共 20 条

[1]

BLAHA CD, 1992, IN PRESS J NEUROSCI

[2] CHOLINERGIC INPUT TO DOPAMINERGIC-NEURONS IN THE SUBSTANTIA-NIGRA - A DOUBLE IMMUNOCYTOCHEMICAL STUDY [J].

BOLAM, JP ;

FRANCIS, CM ;

HENDERSON, Z .

NEUROSCIENCE, 1991, 41 (2-3) :483-494

[3]

BOWMAN WC, 1980, TXB PHARM

[4]

BUCKLEY NJ, 1989, MOL PHARMACOL, V35, P469

[5] RECIPROCAL INFLUENCES OF ACTIVATING AND IMMOBILIZING STIMULI ON THE ACTIVITY OF NIGROSTRIATAL DOPAMINE NEURONS [J].

CHIODO, LA ;

CAGGIULA, AR ;

ANTELMAN, SM ;

LINEBERRY, CG .

BRAIN RESEARCH, 1979, 176 (02) :385-390

[6] AUTORADIOGRAPHIC EVIDENCE FOR NICOTINE RECEPTORS ON NIGROSTRIATAL AND MESOLIMBIC DOPAMINERGIC-NEURONS [J].

CLARKE, PBS ;

PERT, A .

BRAIN RESEARCH, 1985, 348 (02) :355-358

[7] BEHAVIORAL RECOVERY FOLLOWING TRANSPLANTATION OF SUBSTANTIA NIGRA IN RATS SUBJECTED TO 6-OHDA LESIONS OF THE NIGROSTRIATAL PATHWAY .2. BILATERAL LESIONS [J].

DUNNETT, SB ;

BJORKLUND, A ;

STENEVI, U ;

IVERSEN, SD .

BRAIN RESEARCH, 1981, 229 (02) :457-470

[8] CHOLINERGIC PROJECTIONS TO THE SUBSTANTIA NIGRA FROM THE PEDUNCULOPONTINE AND LATERODORSAL TEGMENTAL NUCLEI [J].

GOULD, E ;

WOOLF, NJ ;

BUTCHER, LL .

NEUROSCIENCE, 1989, 28 (03) :611-623

[9]

KEMP JA, 1977, P BRIT PHARM SOC, P507

[10]

LACEY MG, 1990, J PHARMACOL EXP THER, V253, P395

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