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PRODUCTION OF PROSTAGLANDIN-E2 INDUCED BY HISTAMINE BY CLONED RHEUMATOID SYNOVIAL-CELLS

被引：3
作者：
SASANO, M
GOTO, M
NISHIOKA, K
机构：
[1] TOKYO WOMENS MED COLL,INST RHEUMATOL,BOX 116,NS BLD 7F,2-4-1 NISHI SHINJUKU,SHINJUKU KU,TOKYO 163,JAPAN
[2] METROPOLITAN OTSUKA HOSP,DIV RHEUMAT DIS,OTSU,JAPAN
来源：
ANNALS OF THE RHEUMATIC DISEASES | 1990年 / 49卷 / 07期
关键词：
D O I：
10.1136/ard.49.7.504
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Production of prostaglandin E2, with or without histamine stimulation, by three different types of cloned rheumatoid synovial cells (macrophage like, dendritic, and fibroblast like) was evaluated. The ability of these cloned cells to respond to histamine on a cell to cell basis was as follows: macrophage like cells responded most strongly, followed by dendritic cells, followed by fibroblast like cells. Production of prostaglandin E 2, stimulated by histamine, may have a role in bony destruction in rheumatoid joints.
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页码：504 / 506
页数：3
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