MOCLOBEMIDE IN DEPRESSION - A RANDOMIZED, MULTICENTER TRIAL AGAINST ISOCARBOXAZIDE AND CLOMIPRAMINE EMPHASIZING ATYPICAL DEPRESSION

被引：42

作者：

LARSEN, JK

GJERRIS, A

HOLM, P

ANDERSEN, J

BILLE, A

CHRISTENSEN, EM

HOYER, E

JENSEN, H

MEJLHEDE, A

LANGAGERGAARD, A

LAURSEN, AL

NILAKANTAN, B

OLAFSSON, K

SEVERIN, B

RAFAELSEN, OJ

机构：

[1] ST HANS PSYCHIAT HOSP, ROSKILDE, DENMARK

[2] ROCHE AS, DEPT INT CLIN RES, HVIDOVRE, DENMARK

[3] VORDINGBORG PSYCHIAT HOSP, VORDINGBORG, DENMARK

[4] BISPEBJERG HOSP, DEPT PSYCHIAT, DK-2400 COPENHAGEN, DENMARK

[5] HJORRING HOSP, DEPT PSYCHIAT, HJORRING, DENMARK

[6] RIGSHOSP, DEPT PSYCHIAT, DK-2100 COPENHAGEN, DENMARK

来源：

ACTA PSYCHIATRICA SCANDINAVICA | 1991年 / 84卷 / 06期

关键词：

MONOAMINE OXIDASE INHIBITOR; MOCLOBEMIDE; ISOCARBOXAZIDE; CLOMIPRAMINE; ATYPICAL DEPRESSION;

D O I：

10.1111/j.1600-0447.1991.tb03196.x

中图分类号：

R749 [精神病学];

学科分类号：

100205 ;

摘要：

Moclobemide was compared with isocarboxazide and clomipramine in patients with depression. A total of 167 outpatients were allocated to daily treatment with 300 mg moclobemide, 30 mg isocarboxazide or 150 mg clomipramine for 6 weeks. Moclobemide was slightly inferior to clomipramine, whereas isocarboxazide had an intermediate position. There was no interaction between treatment and atypical or nonatypical depression. Anticholinergic symptoms and orthostatic hypotension were most pronounced in the clomipramine group.

引用

页码：564 / 570

页数：7

共 35 条

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