PURIFIED ANTICHICK THY-1 IGG ABOLISHES INTERMEDIATE AND LONG-TERM-MEMORY

被引：4

作者：

FENG, H ^{[1
]}

ZHAO, WQ ^{[1
]}

BERNARD, CCA ^{[1
]}

NG, KT ^{[1
]}

SEDMAN, G ^{[1
]}

机构：

[1] LA TROBE UNIV,DEPT PSYCHOL,BUNDOORA,VIC 3083,AUSTRALIA

来源：

PHYSIOLOGY & BEHAVIOR | 1993年 / 53卷 / 02期

关键词：

DAY-OLD CHICKS; PURIFIED IGG; THY-1; INTERMEDIATE MEMORY; LONG-TERM MEMORY;

D O I：

10.1016/0031-9384(93)90196-M

中图分类号：

B84 [心理学];

学科分类号：

04 ; 0402 ;

摘要：

One- to 2-day-old chicks administered purified antichick Thy-1 IgG showed substantial amnesia for a single-trial passive discriminated avoidance task. Amnesia was clearly evident at 30 min after learning, during the intermediate stage of a three-stage model of memory processing, and persisted for at least 3 h. A similar effect was also observed with Fab and F(ab')2 fragments. Fc fragments, the non-IgG fraction of ascites, and saline yielded normal retention levels at ail times. These results contrast with our earlier reports that both polyclonal and monoclonal antibodies to chick Thy-1 inhibited long-term memory formation only. The present findings are interpreted as possibly representing a dual effect of the purified IgG.

引用

页码：215 / 219

页数：5

共 17 条

[1] INHIBITION OF LONG-TERM-MEMORY FORMATION IN THE CHICKEN BY ANTI CHICK THY-1 ANTIBODY [J].