PREDOMINANTLY VEGETARIAN DIET IN PATIENTS WITH INCIPIENT AND EARLY CLINICAL DIABETIC NEPHROPATHY - EFFECTS ON ALBUMIN EXCRETION RATE AND NUTRITIONAL-STATUS

被引：76

作者：

JIBANI, MM ^{[1
]}

BLOODWORTH, LL ^{[1
]}

FODEN, E ^{[1
]}

GRIFFITHS, KD ^{[1
]}

GALPIN, OP ^{[1
]}

机构：

[1] RENA UNIT,BANGOR LL57 2PW,GWYNEDD,WALES

来源：

DIABETIC MEDICINE | 1991年 / 8卷 / 10期

关键词：

TYPE-1; DIABETES-MELLITUS; ALBUMIN EXCRETION RATE; DIETARY PROTEIN INTAKE; VEGETARIAN DIET;

D O I：

10.1111/j.1464-5491.1991.tb01535.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Several studies have suggested that dietary protein quality may be an important determinant in the natural history of renal disease. We have therefore studied the effects of a predominantly vegetarian diet in eight patients with Type 1 diabetes mellitus and an albumin excretion rate (AER) in excess of 30-mu-g min-1. The AER was measured after an 8-week run-in period on the patient's usual diet, and again after 8 weeks of a predominantly vegetarian diet in which the proportion of vegetable protein was supplemented in order to minimize the reduction in total dietary protein intake. The median fractional albumin clearance fell during the study from an initial value of 188 x 10(-4) (range 58-810 x 10(-4)) at the end of the run-in period to 87 x 10(-4) (23-829 x 10(-4)) at the end of the period on low animal protein diet (difference 79 x 10(-4) (95% CI 9-149 x 10(-4)), p < 0.05). The AER then returned to values similar to those obtained at the beginning of the study after a further 8 weeks in those patients returning to their usual diet. No significant changes in blood glucose control or in arterial pressure were observed. A predominantly vegetarian diet may therefore have important beneficial effects on diabetic nephropathy without the need for a heavily restricted total protein intake.

引用

页码：949 / 953

页数：5

共 31 条

[1] Nath KA, Kren SM, Hostetter TH, Dietary protein restriction in established renal injury in the rat: selective role of glomerular capillary pressure in progressive glomerular dysfunction, J Clin Invest, 78, pp. 1199-1205, (1986)
[2] Maschio G., Oldrizzi L., Tessitore N., Et al., Effects of dietary protein and phosphorus restriction on the progression of early renal failure, Kidney Int, 22, pp. 371-376, (1982)
[3] Ihle BU, Becker GJ, Whitworth JA, Charlwood RA, Kincaid-Smith PS, The effect of protein restriction on the progression of renal insufficiency, N Engl J Med, 321, pp. 1773-1777, (1989)
[4] Rosman JB, Meijer S., Sluitter WJ, Ter Wee PM, Piers-Becht TP, Donker AJ, Prospective randomised trial of dietary protein restriction in chronic renal failure, Lancet, 2, pp. 1291-1296, (1984)
[5] Nahas, Masters-Thomas A., Brady SA, Et al., The effect of low protein diets in chronic renal diseases, Br Med J, 289, pp. 1337-1341, (1984)
[6] Attman PO, Bucht H., Larsson O., Uddebom G., Protein‐reduced diet in diabetic renal failure, Clin Nephrol, 19, pp. 217-220, (1983)
[7] Brouhard BH, Lagrone L., Effect of dietary protein restriction on functional renal reserve in diabetic nephropathy, Am J Med, 89, pp. 427-431, (1990)
[8] Walker JD, Dodds RA, Murrells TJ, Et al., Restriction of dietary protein and progression of renal failure in diabetic nephropathy, Lancet, 2, pp. 1411-1414, (1989)
[9] Cohen D., Dodds R., Viberti GC, Effect of protein restriction in insulin dependent diabetics at risk of nephropathy, Br Med J, 294, pp. 795-798, (1987)
[10] Margetts BM, Beilin LJ, Vandongen R., Armstrong BK, Vegetarian diet in mild hypertension: A randomised controlled trial, Br Med J, 293, pp. 1468-1471, (1986)

← 1 2 3 4 →