NEUTRALIZATION OF FELINE IMMUNODEFICIENCY VIRUS BY POLYCLONAL FELINE ANTIBODY - SIMULTANEOUS INVOLVEMENT OF HYPERVARIABLE REGION-4 AND REGION-5 OF THE SURFACE GLYCOPROTEIN

被引：24

作者：

SIEBELINK, KHJ

HUISMAN, W

KARLAS, JA

RIMMELZWAAN, GF

BOSCH, ML

OSTERHAUS, ADME

机构：

[1] ERASMUS UNIV ROTTERDAM,INST VIROL,3000 DR ROTTERDAM,NETHERLANDS

[2] WASHINGTON UNIV,DEPT PATHOBIOL,SEATTLE,WA

[3] UNIV WASHINGTON,REG PRIMATE RES CTR,SEATTLE,WA 98195

来源：

JOURNAL OF VIROLOGY | 1995年 / 69卷 / 08期

关键词：

D O I：

10.1128/JVI.69.8.5124-5127.1995

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Sites involved in antibody-mediated neutralization of feline immunodeficiency virus were mapped by reciprocal exchange of envelope fragments or amino acids between molecular clones of feline immunodeficiency virus with different susceptibilities to neutralization by a polyclonal cat serum. Combinations of mutations within HV-4 or within HV-4 and HV-5 changed the susceptibility of the viruses to neutralizing antibody.

引用

收藏

页码：5124 / 5127

页数：4

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