CEREBELLAR TOXICITY FOLLOWING HIGH-DOSE CYTOSINE-ARABINOSIDE

被引：40

作者：

DWORKIN, LA

GOLDMAN, RD

ZIVIN, LS

FUCHS, PC

机构：

[1] ST VINCENT HOSP & MED CTR, DEPT PATHOL, 9205 SW BARNES RD, PORTLAND, OR 97209 USA

[2] ST VINCENT HOSP & MED CTR, DEPT MED, PORTLAND, OR 97209 USA

[3] ST VINCENT HOSP & MED CTR, DEPT NEUROL, PORTLAND, OR 97209 USA

来源：

JOURNAL OF CLINICAL ONCOLOGY | 1985年 / 3卷 / 05期

关键词：

D O I：

10.1200/JCO.1985.3.5.613

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

A patient with acute cerebellar toxicity following systemic high-dose cytosine arabinoside (ara-C) 3 g/m2/12 h for secondary acute nonlymphocytic leukemia is reported. Initial symptoms of ataxia and dysarthria emerged at 30 g/m2 cumulative dose and persisted without improvement over a 10 wk period. Recurrence and worsening of cerebellar symptoms followed further consolidation treatment with high-dose ara-C. Subsequent autopsy showed extensive Purkinje''s cell damage in the lateral cerebellar hemispheres. Persistent severe toxicity can occur at total doses less than those generally recognized.

引用

页码：613 / 616

页数：4

共 9 条

[1] EARLY AP, 1982, CANCER RES, V42, P1587
[2] HERZIG RH, 1983, BLOOD, V62, P361
[3] LAZARUS HM, 1981, CANCER-AM CANCER SOC, V48, P2577, DOI 10.1002/1097-0142(19811215)48:12<2577::AID-CNCR2820481207>3.0.CO
[4] 2-Z
[5] RUDNICK SA, 1979, CANCER-AM CANCER SOC, V44, P1189, DOI 10.1002/1097-0142(197910)44:4<1189::AID-CNCR2820440404>3.0.CO
[6] 2-O
[7] SALINSKY MC, 1983, CANCER-AM CANCER SOC, V51, P426, DOI 10.1002/1097-0142(19830201)51:3<426::AID-CNCR2820510312>3.0.CO
[8] 2-S
[9] EFFECT OF DOSE AND SCHEDULE ON PHARMACOKINETICS OF HIGH-DOSE CYTOSINE-ARABINOSIDE IN PLASMA AND CEREBROSPINAL-FLUID
SLEVIN, ML
PIALL, EM
AHERNE, GW
HARVEY, VJ
JOHNSTON, A
LISTER, TA
[J]. JOURNAL OF CLINICAL ONCOLOGY, 1983, 1 (09) : 546 - 551

← 1 →