INTRATHECAL SYNTHESIS OF SOLUBLE CLASS-I ANTIGENS IN MULTIPLE-SCLEROSIS

被引：17

作者：

ALVAREZCERMENO, JC

VILLAR, LM

NOCITO, M

BOOTELLO, A

GONZALEZPORQUE, P

机构：

[1] UNIV ALCALA DE HENARES,DEPT MED,ALCALA DE HENARES,SPAIN

[2] HOSP RAMON & CAJAL,DEPT IMMUNOL,MADRID,SPAIN

来源：

JOURNAL OF NEUROIMMUNOLOGY | 1992年 / 36卷 / 01期

关键词：

MULTIPLE SCLEROSIS; CEREBROSPINAL FLUID; SOLUBLE CLASS-I ANTIGEN; MAJOR HISTOCOMPATIBILITY COMPLEX ANTIGEN;

D O I：

10.1016/0165-5728(92)90032-G

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

We have studied the intrathecal synthesis of soluble class I antigens (sHLA), reflected by the index IH = (CSF sHLA/serum sHLA)/(CSF albumin/serum albumin), in multiple sclerosis (MS). IH was increased in patients in relapse, but normal in patients in remission; these findings show that there is a high lymphocyte activation within the central nervous system in patients with clinically active MS.

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收藏

页码：77 / 79

页数：3

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