EFFECTS OF ENDOTHELIN-1 ON CORONARY MICROCIRCULATION IN ISOLATED BEATING HEARTS OF RATS

被引：11

作者：

HOMMA, S

MIYAUCHI, T

GOTO, K

SUGISHITA, Y

SATO, M

OHSHIMA, N ^{[1
]}

机构：

[1] UNIV TSUKUBA,INST BASIC MED SCI,DEPT BIOMED ENGN,TSUKUBA,IBARAKI 305,JAPAN

[2] UNIV TSUKUBA,INST CLIN MED,DEPT INTERNAL MED,TSUKUBA,IBARAKI 305,JAPAN

[3] UNIV TSUKUBA,INST BASIC MED SCI,DEPT PHARMACOL,TSUKUBA,IBARAKI 305,JAPAN

来源：

JOURNAL OF CARDIOVASCULAR PHARMACOLOGY | 1991年 / 17卷

关键词：

INTRAVITAL MICROSCOPE SYSTEM; CORONARY MICROCIRCULATION; FLUORESCENCE MICROANGIOGRAPHY; ENDOTHELIN-1; RAT BEATING HEART;

D O I：

10.1097/00005344-199100177-00078

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

An intravital fluorescence videomicroscope system was used to investigate the pharmacological effects of endothelin-1 (ET-1) on the coronary microcirculation in isolated beating hearts of rats. The heart was perfused by retrograde aortic steady flow with an oxygenated Krebs-Ringer solution containing FITC-dextran. Cumulative injections of ET-1 (1-30 pmol) elicited a dose-dependent increase in perfusion pressure from 52 +/- 15 mm Hg (mean +/- SEM; n = 6) before the ET-1 injection to 104 +/- 23 mm Hg at the ET-1 dose of 30 pmol. A dose-dependent narrowing of microvessels was also observed on a monitor screen. This diffuse vasoconstriction was especially prominent in small arterioles; the maximum vasoconstriction of the smaller arterioles was significantly higher than that of the larger arterioles. These findings suggest that ET-1 may have an important role in governing the coronary resistance and regulating the capillary flow in myocardium.

引用

页码：S276 / S278

页数：3

共 10 条

[1] IMMUNOREACTIVE ENDOTHELIN IN HUMAN-PLASMA - MARKED ELEVATIONS IN PATIENTS IN CARDIOGENIC-SHOCK [J].