THROMBOSES IN CHILDREN WITH ACUTE LYMPHOBLASTIC-LEUKEMIA TREATED WITH THE COALL-PROTOCOLL

被引:14
作者
ECKHOFDONOVAN, S
SCHWAMBORN, D
KORHOLZ, D
MICHELMANN, I
VONKRIES, R
NURNBERGER, W
GOBEL, U
机构
来源
KLINISCHE PADIATRIE | 1994年 / 206卷 / 04期
关键词
D O I
10.1055/s-2008-1046624
中图分类号
R72 [儿科学];
学科分类号
100202 ;
摘要
To see whether the clinical manifestation of thrombotic events or hemorrhagic infarctions appears as a relevant problem when treating children with acute lymphoblastic leukemia (ALL) concerning the COALL therapy-protocoll, we started an inquiry of the participating hospitals. The mentioned protocoll was designed by the German Society for Pediatric Oncology and Hematology to treat ALL in childhood. All participants gave us information about the treatment period from January 1989 to December 1992. In 6 from 286 treated patients a thromboses appeared in clinical terms. None of them was connected with a lethal outcome. There was no observation of a hemorrhagic infarction. The overall thromboses frequency was 2.1%. In 1.4% patients ''symptomatic'' thrombosis developed close to a continious venous catheter, which can be considered as a thrombogene risk factor. About 0.6% (2/286) of the patients developed the thrombotic events without another risk factor. They can be regarded as ''idiopathic''. 1/2 idiopathic thromboses led to a life threatening situation. There are two important factors that can enhance thromboses: 1) the therapy period, especially induction therapy and application of asparaginase and 2) a continious venous catheter. The fact that asparaginase is not used during the induction therapy is a characteristic of the COALL protocoll. It seems to be useful to differentiate between ''idiopathic'' and ''symptomatic'' thrombotic events, because ''symptomatic'' thromboses appear also in non-leukemic diseases quite frequently.
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页码:327 / 330
页数:4
相关论文
共 16 条
[1]  
ECKHOFDONOVAN S, 1993, KLIN PADIATR, V205, P303
[2]  
GUGLIOTTA L, 1992, EUR J HAEMATOL, V49, P63
[3]  
HAIRE WD, 1991, BONE MARROW TRANSPL, V7, P57
[4]   OSTEONECROSIS OF VERTEBRAE IN A CHILD WITH ACUTE LYMPHOCYTIC-LEUKEMIA DURING L-ASPARAGINASE THERAPY [J].
HANADA, T ;
HORIGOME, Y ;
INUDOH, M ;
TAKITA, H .
EUROPEAN JOURNAL OF PEDIATRICS, 1989, 149 (03) :162-163
[5]  
JANKA GE, 1988, LEUKEMIA, V2, P73
[6]  
MIELOT F, 1987, ARCH FR PEDIATR, V44, P161
[7]  
MINIERO R, 1986, AM J PEDIAT HEMATOL, V8, P116
[8]  
OTT N, 1988, AM J PEDIAT HEMATOL, V10, P191
[9]   THE EFFECT OF L-ASPARAGINASE ON ANTITHROMBIN, PLASMINOGEN, AND PLASMA COAGULATION DURING THERAPY FOR ACUTE LYMPHOBLASTIC-LEUKEMIA [J].
PRIEST, JR ;
RAMSAY, NKC ;
BENNETT, AJ ;
KRIVIT, W ;
EDSON, JR .
JOURNAL OF PEDIATRICS, 1982, 100 (06) :990-995
[10]   A SYNDROME OF THROMBOSIS AND HEMORRHAGE COMPLICATING L-ASPARAGINASE THERAPY FOR CHILDHOOD ACUTE LYMPHOBLASTIC-LEUKEMIA [J].
PRIEST, JR ;
RAMSAY, NKC ;
STEINHERZ, PG ;
TUBERGEN, DG ;
CAIRO, MS ;
SITARZ, AL ;
BISHOP, AJ ;
WHITE, L ;
TRIGG, ME ;
LEVITT, CJ ;
CICH, JA ;
COCCIA, PF .
JOURNAL OF PEDIATRICS, 1982, 100 (06) :984-989