FRACTIONATED GAMMA-KNIFE RADIOSURGERY FOR MALIGNANT GLIOMAS - NEUROBIOLOGICAL EFFECTS AND FDG-PET STUDIES

被引：12

作者：

INOUE, HK ^{[1
]}

HAYASHI, S ^{[1
]}

ISHIHARA, J ^{[1
]}

HORIKOSHI, S ^{[1
]}

ZAMA, A ^{[1
]}

HIRATO, M ^{[1
]}

SHIBAZAKI, T ^{[1
]}

ANDOU, Y ^{[1
]}

OHYE, C ^{[1
]}

机构：

[1] HIDAKA HOSP,CTR GAMMA UNIT,TAKASAKI,GUMMA,JAPAN

来源：

STEREOTACTIC AND FUNCTIONAL NEUROSURGERY | 1995年 / 64卷

关键词：

RADIOSURGERY; FRACTION; GLIOMA; BIOLOGIC EFFECTS; GLUCOSE METABOLISM;

D O I：

10.1159/000098786

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Experimental single-dose neural irradiation was performed in rats and monkeys. Acute and 'early' late damage was observed following single high-dose treatments. By contrast, following a single low-dose treatment, neither 'early' nor 'delayed' late damage was noted. Based on these experiments, a clinical trial of fractionated Gamma Knife surgery for malignant gliomas was begun, and patients were followed by FDG-FET studies. An acute response of the tumor was obtained without damage to the surrounding brain. Fractionated Gamma Knife surgery is a potential alternative treatment for malignant gliomas.

引用

页码：249 / 257

页数：9

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