STRUCTURE ACTIVITY RELATIONS OF (2-CHLOROETHYL)NITROSOUREAS .2. KINETIC EVIDENCE OF A NOVEL MECHANISM FOR THE CYTOTOXICALLY IMPORTANT DNA CROSS-LINKING REACTIONS OF (2-CHLOROETHYL)NITROSOUREAS

被引：28

作者：

BUCKLEY, N

BRENT, TP

机构：

[1] UNIV CALIF SAN FRANCISCO,SCH MED,DEPT NEUROL SURG,CTR BRAIN TUMOR RES,SAN FRANCISCO,CA 94143

[2] ST JUDE CHILDRENS RES HOSP,DEPT BIOCHEM & CLIN PHARMACOL,MEMPHIS,TN 38101

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 1988年 / 110卷 / 22期

关键词：

D O I：

10.1021/ja00230a040

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

引用

收藏

页码：7520 / 7529

页数：10

相关论文

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[6] BRENT TP, 1987, CANCER RES, V47, P6185
[7] EVIDENCE THAT O6-ALKYLGUANINE-DNA ALKYLTRANSFERASE BECOMES COVALENTLY BOUND TO DNA CONTAINING 1,3-BIS(2-CHLOROETHYL)-1-NITROSOUREA-INDUCED PRECURSORS OF INTERSTRAND CROSS-LINKS
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[9] CHEMISTRY OF NITROSOUREAS - DECOMPOSITION OF 1,3-BIS(THREO-3-CHLORO-2-BUTYL)-1-NITROSOUREA AND 1,3-BIS(ERYTHRO-3-CHLORO-2-BUTYL)-1-NITROSOUREA
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[10] A REGIOSELECTIVE MECHANISM FOR MUTAGENESIS AND ONCOGENESIS CAUSED BY ALKYLNITROSOUREA SEQUENCE-SPECIFIC DNA ALKYLATION
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