THE IMMUNODOMINANCE OF EPITOPES WITHIN THE TRANSMEMBRANE PROTEIN (GP41) OF HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 MAY BE DETERMINED BY THE HOSTS PREVIOUS EXPOSURE TO SIMILAR EPITOPES ON UNRELATED ANTIGENS

被引：30

作者：

DAVIS, D ^{[1
]}

CHAUDHRI, B ^{[1
]}

STEPHENS, DM ^{[1
]}

CARNE, CA ^{[1
]}

WILLERS, C ^{[1
]}

LACHMANN, PJ ^{[1
]}

机构：

[1] ADDENBROOKES HOSP,DEPT GENITOURINARY MED,CAMBRIDGE CB2 2QQ,ENGLAND

来源：

JOURNAL OF GENERAL VIROLOGY | 1990年 / 71卷

关键词：

D O I：

10.1099/0022-1317-71-9-1975

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Six major epitopes have been recognized within the transmembrane gp41 molecule of human immunodeficiency virus type 1 (HIV-1). The immunodominant epitope is also recognized by antibodies in sera from laboratory personnel and is similar to a linear sequence of amino acids in the genome protein of two rhinovirus serotypes. The hypothesis is presented that immunodominance is produced by multiple priming of the host, following repeated infections with viruses unrelated to HIV-1, which share similar epitopes.

引用

页码：1975 / 1983

页数：9

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