DIASTEREOSELECTIVITY IN THE OSMIUM TETRAOXIDE PROMOTED DIHYDROXYLATION OF CHIRAL (E)-CROTYLSILANES - ASYMMETRIC-SYNTHESIS OF SILYL-FUNCTIONALIZED GAMMA-LACTONES

被引：35

作者：

PANEK, JS

ZHANG, J

机构：

[1] Department of Chemistry, Metcalf Center for Science and Engineering, Boston University, Boston

来源：

JOURNAL OF ORGANIC CHEMISTRY | 1993年 / 58卷 / 02期

关键词：

D O I：

10.1021/jo00054a002

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The catalytic osmylation of enantiomerically enriched (E)-crotylsilanes (2S,3R)-1 and (2R,3R)-2 containing a homoallylic, nitrogen-bearing stereocenter proceeds with good to high levels of diastereoselection generating silyl-functionalized trans-4,5 substituted gamma-lactones 3 and 5 as the major diastereomers.

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页码：294 / 296

页数：3

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