ANTIHYPERTENSIVE PRINCIPLES FROM THE LEAVES OF MELASTOMA-CANDIDUM

被引：45

作者：

CHENG, JT ^{[1
]}

HSU, HL ^{[1
]}

CHEN, HF ^{[1
]}

机构：

[1] TAIPEI MED COLL,SCH PHARM,TAIPEI 10502,TAIWAN

来源：

PLANTA MEDICA | 1993年 / 59卷 / 05期

关键词：

MELASTOMA-CANDIDUM; ANTIHYPERTENSION; CASTALAGIN; PROCYANIDIN-B-2; HELICHRYSOSIDE; SPONTANEOUSLY HYPERTENSIVE AT (SHR);

D O I：

10.1055/s-2006-959719

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Three active principles were isolated from the leaf of Melastoma candidum using the screening of hypotensive effects on spontaneously hypertensive rats (SHR). Intravenous injection of castalagin, procyanidin B-2, or helichrysoside into SHR lowered the mean blood pressure in a dose-dependent manner, with helichrysoside being the most potent compound. Plasma noradrenaline (NA) levels, both basal in SHR and elevated in normal rats through cold-stress stimulation, were attenuated by these compounds in a way which was not influenced by adrenalectomy. Decrease of NA release from sympathetic nerves was assumed to be responsible. Moreover, the hypertensive effect of various vasoconstrictors in anesthetized rats was reduced by helichrysoside. The same results were also observed in castalagin or procyanidin B-2 treated animals. The results indicate that the three principles possess the ability to lower blood pressure through a decrease of sympathetic tone as well as due to direct vasodilatation in SHRs.

引用

页码：405 / 407

页数：3

共 16 条

[1] NORADRENALINE RELEASE IN RATS DURING PROLONGED COLD-STRESS AND REPEATED SWIM-STRESS [J].