A PHARMACOKINETIC COMPARISON OF CYCLOSPORINE ORAL SOLUTION AND CYCLOSPORINE CAPSULES IN HEART AND LUNG-TRANSPLANT RECIPIENTS

被引：2

作者：

EADON, H

ROSE, M

ONEILL, R

LEAVER, N

YACOUB, M

机构：

[1] Department of Pharmacy, Harefield Hospital, Harefield, UB9 6JH, Middlesex

[2] Department of Immunology, Harefield Hospital, Harefield, UB9 6JH, Middlesex

[3] Department of Pharmaceutics, School of Pharmacy, University of London

[4] Department of Cardiac Surgery, Harefield Hospital, Harefield, UB9 6JH, Middlesex

来源：

TRANSPLANT INTERNATIONAL | 1995年 / 8卷 / 01期

关键词：

CYCLOSPORINE; PHARMACOKINETICS; HEART TRANSPLANTATION; LUNG TRANSPLANTATION;

D O I：

10.1007/BF00366708

中图分类号：

R61 [外科手术学];

学科分类号：

摘要：

Pharmacokinetic profiles were obtained for 16 heart or lung recipients following the administration of identical doses of cyclosporin as oral solution and capsules on consecutive days. A comparison of pharmacokinetic parameters (AUC, C-max, C-min and t(max)) showed that there were no significant differences between the two formulations except for the t(max), which was significantly longer for the capsules. The mean variation in day-to-day trough levels produced by the two different forms was 25.6 %. A retrospective study was carried out of consecutive cyclosporin levels in patients at steady state on oral solution. The mean variation in day-to-day trough levels was 32.3 %. This was not significantly different from the variation in consecutive trough levels seen in the oral solution/capsule comparison. This study shows that cyclosporin capsules can be substituted for oral solution without causing acute changes in cyclosporin blood levels, and that the pharmacokinetics of the two formulations are similar.

引用

页码：35 / 40

页数：6

共 16 条

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